Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150
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AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complexTRPV1: A Target for Rational Drug DesignThe mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependenceTRPV1 and SP: key elements for sepsis outcome?TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channelN-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channelβ-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin.Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscleAKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.Transient receptor potential (TRP) channels: a clinical perspectiveA-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception.The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.[EXPRESS] Primary sensory neuron-specific interference of TRPV1 signaling by AAV-encoded TRPV1 peptide aptamer attenuates neuropathic pain.[EXPRESS] Epac and Nociceptor Sensitization.Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150.Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors.Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphateActivity and Ca²⁺ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons.Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site.Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykininScaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquineBradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors.Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons.Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.AKAP signaling complexes: pointing towards the next generation of therapeutic targets?A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1Activation of the TRPV4 ion channel is enhanced by phosphorylation.Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain.New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia
P2860
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P2860
Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/14)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/14)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية (نشرت في 14-8-2008)
@ar
name
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@ast
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@en
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@nl
type
label
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@ast
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@en
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@nl
prefLabel
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@ast
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@en
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@nl
P2093
P3181
P1433
P1476
Proinflammatory mediators modu ...... scaffolding protein AKAP79/150
@en
P2093
Peter A. McNaughton
Xuming Zhang
P304
P3181
P356
10.1016/J.NEURON.2008.05.015
P407
P577
2008-08-14T00:00:00Z