Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent
about
Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channelsMulti-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channelActivation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction.Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.Alcohol modulation of BK channel gating depends on β subunit compositionBK channels in rat and human pulmonary smooth muscle cells are BKα-β1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert.Lipid regulation of BK channel function.Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunitsBisphenol A activates BK channels through effects on α and β1 subunits.Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat.Dietary cholesterol protects against alcohol-induced cerebral artery constriction.Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2.Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit.Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction.Restoration of the response of the middle cerebral artery of the rat to acidosis in hyposmotic hyponatremia by the opener of large-conductance calcium sensitive potassium channels (BKCa).Large conductance voltage- and calcium-gated potassium channels (BK) in cerebral artery myocytes of perinatal fetal primates share several major characteristics with the adult phenotype
P2860
Q28249053-1BC00550-D6B0-487C-BE5D-7AEDE4CDDBFFQ34716894-717675F5-A9D7-49BE-AEFD-380484371086Q34737890-0ACC4896-F257-4D6C-8CC3-D32831B10660Q36432315-F6B605EA-0956-4DD2-BA98-B1D3DD798119Q37032053-36A7A7A6-CCEE-47F4-8EDB-3B77C9951B0BQ37385468-73F96F7B-CA1B-4370-AF3E-4BCDECC2EAE0Q37555406-74DD3E89-F74F-4AAA-AC93-3B322F8F4716Q38247279-58FAB5CF-0D82-481E-9E9E-92E17E02DD13Q38262897-45EBF987-85BB-475D-8F3C-1E616C2D0B2DQ39029227-B27F2356-4418-404B-A2F5-89443DBACA75Q39067351-FD50835D-9876-4B39-9B3F-26E8893DF58BQ39227861-7CD30FD7-1C0C-4E17-9A32-ECCFAC1A393DQ43077333-CE6E9872-622F-48E6-8CA6-BADB46B60955Q46302314-42BA0309-067C-4EFA-99B3-FCA4AAA28CC9Q47393377-4A8C1836-B3AE-44C6-A1B1-0263BB6204D6Q49247567-9DE55A3A-EDC3-4B23-BA53-F5DE18ACDAEFQ51213223-151FF544-3977-446E-B336-94D396FAD784Q58744394-1DDECB4A-1EFC-4549-BDE8-6D4E8654B9CD
P2860
Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent
description
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Mai 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/05/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/05/01)
@nl
наукова стаття, опублікована в травні 2013
@uk
مقالة علمية (نشرت في مايو 2013)
@ar
name
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@ast
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@en
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@nl
type
label
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@ast
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@en
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@nl
prefLabel
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@ast
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@en
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@nl
P2093
P2860
P356
P1476
Cerebrovascular dilation via s ...... by a novel nonsteroidal agent
@en
P2093
Abby L. Parrill
Alex M. Dopico
Alexander L. Fedinec
Anna N. Bukiya
Charles W. Leffler
Duane D. Miller
Jacob E. McMillan
Shivaputra A. Patil
P2860
P304
P356
10.1124/MOL.112.083519
P577
2013-05-01T00:00:00Z