c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
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Anti-diabetes drug pioglitazone ameliorates synaptic defects in AD transgenic mice by inhibiting cyclin-dependent kinase5 activityEphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomersCdk5 activity in the brain - multiple paths of regulation.Oxidative stress, mitochondrial damage and neurodegenerative diseasesAltered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathologyThe role of tau kinases in Alzheimer's disease.Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway.High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signalingAmyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism.Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain.Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease.Parkinson's disease: a complex interplay of mitochondrial DNA alterations and oxidative stress.The importance of tau phosphorylation for neurodegenerative diseasesc-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.c-Abl in neurodegenerative diseaseDoes the small tyrosine kinase inhibitor Imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?The Role of Cdk5 in Alzheimer's Disease.Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis.Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance.Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.Identification of abelson tyrosine kinase inhibitors as potential therapeutics for Alzheimer's disease using multiple e-pharmacophore modeling and molecular dynamics.Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.Cognitive dysfunction after withdrawal of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia.Altered expression of c-Abl in patients with epilepsy and in a rat model.The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.
P2860
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P2860
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
description
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Juli 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/07/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/07/01)
@nl
наукова стаття, опублікована в липні 2011
@uk
مقالة علمية (نشرت في يوليو 2011)
@ar
name
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@ast
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@en
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@nl
type
label
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@ast
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@en
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@nl
prefLabel
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@ast
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@en
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@nl
P2093
P1476
c-Abl tyrosine kinase modulate ...... rylation in AD transgenic mice
@en
P2093
Alejandra R Alvarez
Gonzalo I Cancino
Karen Perez de Arce
Paula U Castro
P304
P356
10.1016/J.NEUROBIOLAGING.2009.07.007
P577
2009-08-22T00:00:00Z