Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly
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Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assayMembers of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptorPEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import.ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)Potential role for Pex19p in assembly of PTS-receptor docking complexesProperties of the ubiquitin-pex5p thiol ester conjugate.A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway.Reducing PEX13 expression ameliorates physiological defects of late-acting peroxin mutants.Ubiquitination of mammalian Pex5p, the peroxisomal import receptor.Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexes.The peroxisomal protein import machinery displays a preference for monomeric substrates.Revisiting the intraperoxisomal pathway of mammalian PEX7.Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway.Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.Novel mutations in the PEX2 gene of four unrelated patients with a peroxisome biogenesis disorder.Multiple pathways for protein transport to peroxisomes.Protein transport into peroxisomes: Knowns and unknowns.Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import.Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell mutant, ZPEG101.Lipid rafts are essential for peroxisome biogenesis in HepG2 cells.Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system.The energetics of Pex5p-mediated peroxisomal protein import.The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol.The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step.Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins.Import of the peroxisomal targeting signal type 2 protein 3-ketoacyl-coenzyme a thiolase into glyoxysomes.Leishmania donovani peroxin 14 undergoes a marked conformational change following association with peroxin 5.Peroxisomal protein import
P2860
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P2860
Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/08/10)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/10)
@nl
наукова стаття, опублікована в серпні 2001
@uk
name
Characterization of the mammal ...... s of the same protein assembly
@ast
Characterization of the mammal ...... s of the same protein assembly
@en
Characterization of the mammal ...... s of the same protein assembly
@nl
type
label
Characterization of the mammal ...... s of the same protein assembly
@ast
Characterization of the mammal ...... s of the same protein assembly
@en
Characterization of the mammal ...... s of the same protein assembly
@nl
prefLabel
Characterization of the mammal ...... s of the same protein assembly
@ast
Characterization of the mammal ...... s of the same protein assembly
@en
Characterization of the mammal ...... s of the same protein assembly
@nl
P2093
P2860
P356
P1476
Characterization of the mammal ...... s of the same protein assembly
@en
P2093
A. M. Gouveia
C. Reguenga
C. Sá-Miranda
J. E. Azevedo
M. E. Oliveira
P2860
P304
29935–29942
P356
10.1074/JBC.M104114200
P407
P577
2001-08-10T00:00:00Z