Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia
about
Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent mannerRegular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty ratsActivation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscleRole of ceramide in diabetes mellitus: evidence and mechanisms.Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscle.Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL.CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes.Dietary enrichment with fish oil prevents high fat-induced metabolic dysfunction in skeletal muscle in mice.High intensity interval and endurance training have opposing effects on markers of heart failure and cardiac remodeling in hypertensive rats.Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cellsOf mice and men: the benefits of caloric restriction, exercise, and mimetics.Exercise training is an effective alternative to estrogen supplementation for improving glucose homeostasis in ovariectomized rats.Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adultsEffects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats.Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventionsSphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity.Evaluation of treadmill exercise effect on muscular lipid profiles of diabetic fatty rats by nanoflow liquid chromatography-tandem mass spectrometry.FAT/CD36 expression is not ablated in spontaneously hypertensive rats.Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.The role of skeletal muscle sphingolipids in the development of insulin resistanceThe effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolismGreater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal musclePGC-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions.Adipokines as regulators of muscle metabolism and insulin sensitivity.Targeting insulin sensitivity in the treatment of polycystic ovary syndrome.Soluble CD36- a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism.Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle.Effect of pioglitazone on plasma ceramides in adults with metabolic syndrome.AICAR inhibits ceramide biosynthesis in skeletal muscle.Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers.Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats.Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate.Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats.
P2860
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P2860
Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia
description
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
scientific journal article
@en
vedecký článok (publikovaný 2007/07/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/07/01)
@nl
наукова стаття, опублікована в липні 2007
@uk
مقالة علمية (نشرت في يوليو 2007)
@ar
name
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@ast
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@en
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@nl
type
label
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@ast
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@en
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@nl
prefLabel
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@ast
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@en
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@nl
P2093
P2860
P3181
P1476
Metformin and exercise reduce ...... fat diet-induced hyperglycemia
@en
P2093
Angela C. Smith
Arend Bonen
David J. Dyck
Jennifer Nickerson
Kathryn A. Junkin
Kerry L. Mullen
P2860
P304
P3181
P356
10.1152/AJPENDO.00677.2006
P577
2007-07-01T00:00:00Z