EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio
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Systematic identification of regulatory proteins critical for T-cell activationSphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinasesActions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in miceLigand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progressLipid phosphate phosphatase (LPP3) and vascular developmentDifferential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptorsSphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptaseAssembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contactsExtracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cellsMolecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosisBlood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney diseaseThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsB lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors.G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways.Novel GPCR screening approach: indirect identification of S1P receptor agonists in antagonist screening using a calcium assay.Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cellsSphingosine kinase and sphingosine 1-phosphate in cardioprotection.Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitizationSphingosine 1-phosphate signalling in mammalian cells.STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeSphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathwayFingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling.Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathwayAcid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factorsSphingolipids in inflammation: pathological implications and potential therapeutic targets.Ceramide signaling in mammalian epidermis.Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.The influences of metabotropic receptor activation on cellular signaling and synaptic function in amacrine cells.Sphingosine-1-phosphate signaling in physiology and diseases.Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).Molecular recognition in the sphingosine 1-phosphate receptor family.
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P2860
EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio
description
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im Oktober 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/10/16)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/10/16)
@nl
наукова стаття, опублікована в жовтні 1998
@uk
name
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@ast
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@en
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@nl
type
label
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@ast
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@en
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@nl
prefLabel
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@ast
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@en
EDG1 is a functional sphingosi ...... nd adenylate cyclase inhibitio
@nl
P2093
P3181
P356
P1476
EDG1 is a functional sphingosi ...... d adenylate cyclase inhibition
@en
P2093
H Shigematsu
P304
27104-27110
P3181
P356
10.1074/JBC.273.42.27104
P407
P50
P577
1998-10-01T00:00:00Z