Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 - Wikidata - awgldk - TriplyDB

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

http://www.wikidata.org/entity/Q28583647

about

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2 The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction Downregulation of Reactive Oxygen Species in Apoptosis The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelism Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage Regulation of Drosophila metamorphosis by xenobiotic response regulators Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum Mechanistic studies of the Nrf2-Keap1 signaling pathway Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2 Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms Comparison of human Nrf2 antibodies: A tale of two proteins PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders Aging and immune function: molecular mechanisms to interventions Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase The complexity of the Nrf2 pathway: beyond the antioxidant response HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Mechanism of chemical activation of Nrf2 Further structure-activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways.Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells.Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15 Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms.Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.Effects of interventions on oxidative stress and inflammation of cardiovascular diseases The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases.Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose.

P2860

Q23923854-7BF5C4C1-6118-47F0-A566-29794CF57952 Q24170512-3550A8E3-E3E9-4F36-9AF7-6B11CC89E66E Q24297188-612B0BE1-AF32-47F3-9809-6F5061528829 Q24310885-BD56AF19-2D5F-400C-9C69-65F197D7E2B7 Q24648021-9E2B879B-8B92-4644-891F-6BECDCC21290 Q24656061-E6BEFF4D-A807-4361-9238-ADB4C8803ADE Q26751139-6361CF5D-CB74-4F8D-A057-505DF8001073 Q26822972-D5137415-B33E-401B-8D0B-52DCDC9141AD Q26852148-EE541833-069C-44F5-896E-8675616B81A0 Q26995211-507140A8-5895-497E-ADB2-639CCF3EA8E7 Q27324641-432034BA-65B3-458B-80D9-A8CC746ED4EB Q28079206-949F8201-F329-44E6-840A-20C30C59EAFE Q28239381-5696E69E-94AF-4074-A653-A3CCFC2904CF Q28254462-7889335E-6048-4C0E-80CA-05B43072F626 Q28277182-30961F7B-E261-45B5-9212-01EF1D2755F6 Q28277430-764B7D38-3967-403F-ABA8-9BDF59A3898F Q28301456-87C72F52-0659-4561-ADC4-198BCE680439 Q28382872-EC7298E9-FE2B-4F5E-B4B4-1422ACFA98AC Q28383318-8C5FF617-B33F-423E-AE96-BC46059959F3 Q28383343-0E24FF58-F211-49EF-9EC7-3DFCE75D73BA Q28384526-534FF16D-1039-4446-99A1-B8A1EE00B489 Q28386313-BEB2E0A2-F61D-4D24-9422-CA321D509391 Q28387056-3B4A80B9-05D1-4237-8CC6-01CAE73DA93F Q28389107-B5E7EB62-9F67-4D04-A5F8-AC70BB8A8F70 Q28389296-8E577D07-6B42-4659-AF84-831620DA6396 Q28394040-10192560-5DC8-4EF3-A64B-50698B81A246 Q28398010-5B9F3065-0742-485D-B971-AA9629A17B85 Q28482975-546C2D1E-55BA-45B9-AA21-0F99780602D3 Q28821625-948B31D0-846A-4813-AF75-3A8321349753 Q33463931-43FAFF38-F161-4442-A04D-9C687309AA5C Q33783238-CEF0ECA5-9EDF-4776-9A3F-18FFBC147925 Q33815276-F7016F73-E93A-474E-ABA3-BE0F094587B8 Q33824170-833C1F79-9D5E-4436-8ECF-01F481144B76 Q34003929-4AB98E94-B208-4DA1-B199-B5DD6701B589 Q34067581-F6B0D580-2B50-42FE-9C87-408E49F46A1A Q34104944-4A5679A9-9C49-4F01-A6FB-D8EBCE665B1C Q34415050-81E80C6F-668C-4CE8-B8BA-528F2E7E3806 Q34538729-E9FDF3B9-6899-4945-89BA-BB0703940669 Q34552443-7E269A5B-8FEE-40B7-8BAE-DBD2F79ED194 Q34657424-0B719A0A-63B0-4CE9-AA54-3B24EE142479

P2860

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

http://www.wikidata.org/entity/Q28583647

description

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2005

@ast

im September 2005 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2005/09/16)

@sk

vědecký článek publikovaný v roce 2005

@cs

wetenschappelijk artikel (gepubliceerd op 2005/09/16)

@nl

наукова стаття, опублікована у вересні 2005

@uk

name

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@ast

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@en

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@nl

type

label

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@ast

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@en

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@nl

prefLabel

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@ast

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@en

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@nl

P1433

Q28583647-AA54F172-55B0-4703-BAC9-BB0AF33EF7D2

P1476

Q28583647-FF9E975F-D516-422F-A92C-1896B459DD04

P2093

Q28583647-02EAF2DF-3D9D-4D39-B736-5BF7E27C0D60

Q28583647-0B4CB045-1C3F-495A-AFF1-6177B19F2761

Q28583647-48B604B1-444C-4307-B868-1E61841785AA

Q28583647-57AE4113-1897-4193-8E79-2348BA6F5823

Q28583647-F65D97AE-DECC-4BC0-A434-7D1D3AF11990

P2860

Q28583647-0381EA31-62D4-4888-90E4-A30BCC12B582

Q28583647-172C354E-8911-408D-94AB-8EA11B705695

Q28583647-183437C1-3EC9-4440-B2C4-9265F13BF904

Q28583647-2054B501-F1DD-4543-B489-C59375829214

Q28583647-230A86EF-5062-41F8-97AB-EEE21655199A

Q28583647-246F34CF-F432-499B-A0FB-262E1DB1EF08

Q28583647-24B91855-7C26-4715-A187-F972769005D9

Q28583647-34E1C739-37FA-40A4-B6CE-1EBA9DA1EB6C

Q28583647-370810F4-BB70-495C-A669-ECE73A43C237

Q28583647-37EFB2D6-0C77-4A27-BABC-625D3385D8CF

P304

Q28583647-9535324E-2091-4F22-86DE-5C08EE61831E

P31

Q28583647-76ED4A4B-EDD1-4B22-BD7A-35C0970EFD1A

P3181

Q28583647-B277BB5D-D129-4243-B073-98A2A74D9482

P356

Q28583647-C84D2A3D-6363-40B5-A6FB-13B09787987F

P407

Q28583647-1DE0EF8B-A2BE-4CC7-B417-8432703182E4

P433

Q28583647-901F1D81-0FD1-4444-9E9B-A68AD8CE8CDA

P478

Q28583647-DAB92942-AC8E-40C1-82EF-F0E45607805A

P577

Q28583647-79E9BC7D-A3BF-4015-A03A-8803A3A760A8

P698

Q28583647-E1A2B60E-DA78-451F-849B-FB6DC5B85BD4

P3181

P356

P1433

Journal of Biological Chemistry

P1476

Nrf2 controls constitutive and ...... cytoplasmic shuttling by Keap1

@en

P2093

Cecil B. Pickett

http://www.w3.org/2001/XMLSchema#string

Chung S. Yang

http://www.w3.org/2001/XMLSchema#string

Paul Nioi

http://www.w3.org/2001/XMLSchema#string

Philip J. Sherratt

http://www.w3.org/2001/XMLSchema#string

Truyen Nguyen

http://www.w3.org/2001/XMLSchema#string

P2860

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

CRM1 is an export receptor for leucine-rich nuclear export signals

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Exportin 1 (Crm1p) is an essential nuclear export factor.

P304

32485–32492

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2899140

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M503074200

http://www.w3.org/2001/XMLSchema#string

P407

P433

37

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2005-09-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16000310

http://www.w3.org/2001/XMLSchema#string