Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus
about
Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single geneQuantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes typePost-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signalingNucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylaseCellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetesExperimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetesHigher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetesGAD, diabetes, and Stiff-Man syndrome: some progress and more questions.Characterization of the rat GAD67 gene promoter reveals elements important for basal transcription and glucose responsiveness.Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus.Mononuclear cytotoxicity and proliferation towards glucose stimulated rodent pancreatic islet cells.Gene expression of receptors and enzymes involved in GABAergic and glutamatergic neurotransmission in the CNS of rats behaviourally dependent on ethanol.Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells.Transcriptome atlas of glutamine family amino acid metabolism-related genes in eight regenerating liver cell types.Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells.Distribution and neurochemical characterization of neurons in the rat ventrolateral medulla activated by glucoprivation.Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.The dopamine D2 receptor subfamily in rat retina: ultrastructural immunogold and in situ hybridization studies.Autoantigenic reactivity of diabetes sera with a hybrid glutamic acid decarboxylase GAD67-65 molecule GAD67(1-101)/GAD65(96-585).Middle-aged female rats lack the dynamic changes in GAD(67) mRNA levels observed in young females on the day of a luteinising hormone surge.
P2860
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P2860
Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus
description
1991 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1991
@ast
im Oktober 1991 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1991/10/01)
@sk
vědecký článek publikovaný v roce 1991
@cs
wetenschappelijk artikel (gepubliceerd op 1991/10/01)
@nl
наукова стаття, опублікована в жовтні 1991
@uk
name
Cloning, characterization, and ...... in-dependent diabetes mellitus
@ast
Cloning, characterization, and ...... in-dependent diabetes mellitus
@en
Cloning, characterization, and ...... in-dependent diabetes mellitus
@nl
type
label
Cloning, characterization, and ...... in-dependent diabetes mellitus
@ast
Cloning, characterization, and ...... in-dependent diabetes mellitus
@en
Cloning, characterization, and ...... in-dependent diabetes mellitus
@nl
prefLabel
Cloning, characterization, and ...... in-dependent diabetes mellitus
@ast
Cloning, characterization, and ...... in-dependent diabetes mellitus
@en
Cloning, characterization, and ...... in-dependent diabetes mellitus
@nl
P2093
P2860
P356
P1476
Cloning, characterization, and ...... in-dependent diabetes mellitus
@en
P2093
A. Møldrup
B. K. Michelsen
J. S. Petersen
O. D. Madsen
T. Dyrberg
P2860
P304
P356
10.1073/PNAS.88.19.8754
P407
P577
1991-10-01T00:00:00Z