Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
about
A novel RASA1 mutation causing capillary malformation-arteriovenous malformation (CM-AVM) presenting during pregnancyAIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in miceA novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability.Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutationsA vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol estersDisruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisRoles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisMicroRNA-mediated regulation of the angiogenic switchMicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesisDesign of versatile biochemical switches that respond to amplitude, duration, and spatial cuesRole of p120 Ras-GAP in directed cell movementSmall G proteins in the cardiovascular system: physiological and pathological aspectsVascular anomalies: from genetics toward models for therapeutic trialsCellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alphaShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.Rasip1 is required for endothelial cell motility, angiogenesis and vessel formationNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesDisruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and divisionRas GTPase-activating protein binds to Akt and is required for its activationThe ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryoYolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TELPartial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells.Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain.Pediatric cerebral cavernous malformations: Genetics, pathogenesis, and management.Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.Mutant huntingtin can paradoxically protect neurons from death.Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.Growth factor signaling pathways in vascular development.RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.Structural analysis of the GAP-related domain from neurofibromin and its implicationsControl of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein.Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.The role of FGF and VEGF in angioblast induction and migration during vascular development.Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.RasGrf1 deficiency delays aging in mice.
P2860
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P2860
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
description
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1995
@ast
scientific journal article
@en
vedecký článok (publikovaný 1995/10/26)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/10/26)
@nl
наукова стаття, опублікована в жовтні 1995
@uk
مقالة علمية (نشرت في 26-10-1995)
@ar
name
Vascular system defects and ne ...... ras GTPase-activating protein
@ast
Vascular system defects and ne ...... ras GTPase-activating protein
@en
Vascular system defects and ne ...... ras GTPase-activating protein
@nl
type
label
Vascular system defects and ne ...... ras GTPase-activating protein
@ast
Vascular system defects and ne ...... ras GTPase-activating protein
@en
Vascular system defects and ne ...... ras GTPase-activating protein
@nl
prefLabel
Vascular system defects and ne ...... ras GTPase-activating protein
@ast
Vascular system defects and ne ...... ras GTPase-activating protein
@en
Vascular system defects and ne ...... ras GTPase-activating protein
@nl
P2093
P356
P1433
P1476
Vascular system defects and ne ...... ras GTPase-activating protein
@en
P2093
D. J. Rossi
D. P. Holmyard
G. Mbamalu
M. C. Puri
M. Henkemeyer
T. S. Shih
P2888
P304
P356
10.1038/377695A0
P407
P577
1995-10-26T00:00:00Z
P6179
1003571771