MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
about
A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat dietAcylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorptionIntestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismCholesterol and lipoprotein dynamics in a hibernating mammalOver-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesityMGL2/YMR210w encodes a monoacylglycerol lipase in Saccharomyces cerevisiae.Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamilyA human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl estersLipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestionPharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat UtilizationLipopenia and skin barrier abnormalities in DGAT2-deficient miceMurine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulumRecruiting a new substrate for triacylglycerol synthesis in plants: the monoacylglycerol acyltransferase pathwayThe biogenesis of chylomicronsHepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.Evolutionary view of acyl-CoA diacylglycerol acyltransferase (DGAT), a key enzyme in neutral lipid biosynthesis.Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity.Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Dietary triacylglycerol structure and its role in infant nutrition.Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intoleranceDeficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain.Role of the gut in modulating lipoprotein metabolism.Gut triglyceride production.Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signalingCharacterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.Lipid droplet formation on opposing sides of the endoplasmic reticulumRegulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation.Role of the gut in lipid homeostasisMogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolismExposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane.Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.
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P2860
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2003
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im Mai 2003 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2003/05/16)
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vědecký článek publikovaný v roce 2003
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wetenschappelijk artikel (gepubliceerd op 2003/05/16)
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наукова стаття, опублікована в травні 2003
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name
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@ast
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@en
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@nl
type
label
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@ast
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@en
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@nl
prefLabel
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@ast
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@en
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
@nl
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P3181
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P1476
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
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P2093
Chi-Liang Eric Yen
Robert V. Farese
P2860
P304
18532–18537
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P356
10.1074/JBC.M301633200
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P577
2003-05-16T00:00:00Z