Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
about
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 moduleCanine polydactyl mutations with heterogeneous origin in the conserved intronic sequence of LMBR1Transcription factor-mediated reprogramming toward hematopoietic stem cellsDistinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud developmentGATA6 is a crucial regulator of Shh in the limb budVertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning systemHeterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin developmentScapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.Control of pelvic girdle development by genes of the Pbx family and Emx2.Essential role for Pbx1 in corneal morphogenesis.Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development.Evolution of vertebrate appendicular structures: Insight from genetic and palaeontological data.Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors.Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.Nipbl and mediator cooperatively regulate gene expression to control limb development.Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds.Axial Hox9 activity establishes the posterior field in the developing forelimb.Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation.A nonsense mutation in the HOXD13 gene underlies synpolydactyly with incomplete penetrance.MLL becomes functional through intra-molecular interaction not by proteolytic processingProteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Hox genes regulate the onset of Tbx5 expression in the forelimb.Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic NeuronsPbx4 is Required for the Temporal Onset of Zebrafish Myocardial DifferentiationMolecular mechanisms of midfacial developmental defects.Gene replacement strategies to test the functional redundancy of basic helix-loop-helix transcription factor.A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb.Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis.Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.An increased duplication of ZRS region that caused more than one supernumerary digits preaxial polydactyly in a large Chinese family.Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.
P2860
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P2860
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
description
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Juni 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/06/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/06/01)
@nl
наукова стаття, опублікована в червні 2006
@uk
مقالة علمية (نشرت في يونيو 2006)
@ar
name
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@ast
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@en
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@nl
type
label
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@ast
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@en
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@nl
prefLabel
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@ast
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@en
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@nl
P2093
P921
P356
P1433
P1476
Pbx1/Pbx2 requirement for dist ...... istribution and Shh expression
@en
P2093
Andrea Brendolan
Deepak Srivastava
Elisabetta Ferretti
Giuseppina Di Giacomo
Licia Selleri
Terence D. Capellini
Valentina Salsi
Vincenzo Zappavigna
P304
P356
10.1242/DEV.02395
P407
P577
2006-06-01T00:00:00Z