Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis
about
Gene regulatory networks in cardiac conduction system developmentThe T-box gene family: emerging roles in development, stem cells and cancerIdentification and functional characterization of cardiac pacemaker cells in zebrafishCanonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndromeLack of genetic interaction between Tbx20 and Tbx3 in early mouse heart developmentCoordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex.Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node.The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy.A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.Transcription factor ISL1 is essential for pacemaker development and function.TBX5 drives Scn5a expression to regulate cardiac conduction system functionGenetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous PoleMild decrease in TBX20 promoter activity is a potentially protective factor against congenital heart defects in the Han Chinese population.T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.Shox2 influences mesenchymal stem cell fate in a co-culture model in vitro.Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.Cardiac troponin T is necessary for normal development in the embryonic chick heart.Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activityDevelopment of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3.Cardiac conduction system anomalies and sudden cardiac death: insights from murine models.Cardiac electrophysiology in mice: a matter of size.Signaling and transcriptional networks in heart development and regeneration.Arrhythmias in the developing heart.Insights into cardiac conduction system formation provided by HCN4 expression.Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.Development of the cardiac pacemakerAssociation analysis identifies new risk loci for congenital heart disease in Chinese populations.Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regenerationInducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.TBX3 Directs Cell-Fate Decision toward Mesendoderm.Essential roles of Tbx3 in embryonic skin development during epidermal stratification.Development and Function of the Cardiac Conduction System in Health and Disease.Specific Cell (Re-)Programming: Approaches and Perspectives.T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.
P2860
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P2860
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@ast
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@en
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@nl
type
label
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@ast
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@en
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@nl
prefLabel
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@ast
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@en
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@nl
P2093
P2860
P3181
P356
P1476
Lethal arrhythmias in Tbx3-def ...... ystem function and homeostasis
@en
P2093
Anne M Moon
Deborah U Frank
Kandis L Carter
Kirk R Thomas
Martijn L Bakker
Martin Tristani-Firouzi
Michael J Bamshad
R Michael Burr
P2860
P304
P3181
P356
10.1073/PNAS.1115165109
P407
P577
2011-12-27T00:00:00Z