Unc45 activates Hsp90-dependent folding of the myosin motor domain
about
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Myosin chaperonesUCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeastX-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogasterApproaches for defining the Hsp90-dependent proteome.Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domainParalysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky tickerA Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility.Lack of developmental redundancy between Unc45 proteins in zebrafish muscle developmentKnockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.Getting folded: chaperone proteins in muscle development, maintenance and disease.Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein traffickingThe UNC-45 myosin chaperone: from worms to flies to vertebrates.Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.Deep sequencing of the murine olfactory receptor neuron transcriptome.Expression of heat shock protein (Hsp90) paralogues is regulated by amino acids in skeletal muscle of Atlantic salmon.Identification of Reproduction-Related Gene Polymorphisms Using Whole Transcriptome Sequencing in the Large White Pig Population.Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter.Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegansStructural basis for drug-induced allosteric changes to human β-cardiac myosin motor activityBuild it up-Tear it down: protein quality control in the cardiac sarcomere.Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases.Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function.Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis.Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally.UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation.Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics.Chaperones and the Proteasome System: Regulating the Construction and Demolition of Striated Muscle.UNC-45a promotes myosin folding and stress fiber assembly.
P2860
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P2860
Unc45 activates Hsp90-dependent folding of the myosin motor domain
description
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2008/05/09)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/05/09)
@nl
наукова стаття, опублікована в травні 2008
@uk
name
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@ast
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@en
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@nl
type
label
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@ast
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@en
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@nl
prefLabel
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@ast
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@en
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@nl
P2093
P2860
P356
P1476
Unc45 activates Hsp90-dependent folding of the myosin motor domain
@en
P2093
Donald A. Winkelmann
Rajani Srikakulam
P2860
P304
13185–13193
P356
10.1074/JBC.M800757200
P407
P577
2008-05-09T00:00:00Z