A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
about
Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNAMammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAsWho Watches the Watchmen: Roles of RNA Modifications in the RNA Interference PathwayThe organization and regulation of mRNA-protein complexesThe insights of Let-7 miRNAs in oncogenesis and stem cell potencyLin28 and let-7 in cell metabolism and cancerSurprises in the 3'-end: 'U' can decide too!The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseaseThreading the barrel of the RNA exosomeProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsPoly(A) polymerase (PAP) diversity in gene expression--star-PAP vs canonical PAPMicroRNA biogenesis pathways in cancerMitochondrial RNA editing in trypanosomes: small RNAs in controlThe human PMR1 endonuclease stimulates cell motility by down regulating miR-200 family microRNAs.Structural analysis of Dis3l2, an exosome-independent exonuclease from Schizosaccharomyces pombeRNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targetingMechanisms of microRNA turnoverLin28 sustains early renal progenitors and induces Wilms tumorMechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathwayBroad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5Single-molecule pull-down for investigating protein-nucleic acid interactions.Lin28a regulates neuronal differentiation and controls miR-9 production.Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processingTailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.Alteration of miRNA activity via context-specific modifications of Argonaute proteins.A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis.Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fateUridylation by TUT4 and TUT7 marks mRNA for degradation.Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCsRescuing dicer defects via inhibition of an anti-dicing nuclease.Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-productDeep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomesThe yin and yang of kidney development and Wilms' tumorsAdenylation of maternally inherited microRNAs by Wispy.The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.Identification of small molecule inhibitors of Zcchc11 TUTase activity.Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.
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P2860
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
description
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2013
@ast
scientific journal article
@en
vedecký článok (publikovaný 2013/05/09)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/05/09)
@nl
наукова стаття, опублікована в травні 2013
@uk
مقالة علمية (نشرت في 9-5-2013)
@ar
name
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@ast
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@en
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@nl
type
label
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@ast
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@en
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@nl
prefLabel
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@ast
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@en
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@nl
P2093
P2860
P3181
P356
P1433
P1476
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
@en
P2093
Hao-Ming Chang
James E. Thornton
Richard I. Gregory
Robinson Triboulet
P2860
P2888
P304
P3181
P356
10.1038/NATURE12119
P407
P577
2013-05-09T00:00:00Z
P5875
P6179
1046553569