Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
about
D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.Chlorpromazine-Induced Hyperprolactinemia on Rat's UterusProlactin cooperates with loss of p53 to promote claudin-low mammary carcinomasHigh expression of prolactin receptor is associated with cell survival in cervical cancer cells.The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cellsProlactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer.Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.The two faces of Janus kinases and their respective STATs in mammary gland development and cancerConstitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesisSrc tyrosyl phosphorylates cortactin in response to prolactin.STAT3 activation is required for the antiapoptotic effects of prolactin in cervical cancer cells.Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse.Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.STAT signaling in mammary gland differentiation, cell survival and tumorigenesisJanus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivoDysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells.Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.Nuclear JAK2: form and function in cancer.HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth.Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.Developmental Contribution of Wnt-signal-responsive Cells to Mouse Reproductive Tract FormationGeneration of Janus kinase 1 (JAK1) conditional knockout mice.Stromal-epithelial interactions modulate cross-talk between prolactin receptor and HER2/Neu in breast cancer.Prolactin promotes hepatocellular carcinoma through Janus kinase 2.
P2860
Q27690967-41BC0244-9336-4032-8251-0C6E64FBCB18Q28607320-CEC68D28-32A0-4289-96C1-F4302F096E3CQ33555787-A1FFDE75-1764-4AE9-AE04-59F1B372760FQ33591458-17E39413-7BF6-4925-BEE0-D3B360AB49A3Q33783277-A80790DD-E168-4AFE-8E49-6B4137DDD78FQ33796523-BC2088BA-0A59-4163-9BFD-68A0E3375D2FQ35029548-EA34F5CF-77A8-492F-BC8D-F77FC252A258Q35623950-DA10E2BE-FBE2-4CA1-A484-9B009665D053Q35683515-8F7C7522-A5D5-4C93-995B-7B8DF831997CQ35685851-7261D93A-9949-437A-9166-F720FEB7892FQ35737909-E282C689-43AC-407D-9D8C-3769A26F3105Q35836464-64B1161F-12F5-442D-8645-279CE3BFEA07Q36027269-89BCDEE6-206B-402E-AF32-039A97C9DF6DQ36629985-0EADEBB4-7946-4794-8496-9BB87FE74EF0Q37068166-E3159205-6FDC-4E2C-9F68-F193683DCBD1Q37107328-FFA0B541-7B88-4387-86EC-3256340C52B6Q37122579-8FE866D3-67DE-4DC6-8F71-0E55974C7D77Q37331101-597E217D-F4E8-4341-812C-9066B5D47B97Q37475469-1AAA917D-3AB6-4751-9E4B-B94BCA633F1EQ37593533-799FABCA-886D-40AB-A29B-F27BA4C4B691Q37713579-E33C667D-0F23-4FD1-95C0-10D79C8859F5Q37910092-8D6202A6-D0FF-4760-90F8-866DE938626CQ38760796-04651D2A-278C-4442-9EE2-8E0D75CD7CD0Q39299570-CB27226C-237E-4FC5-A107-142999DE4BC6Q41332749-B0282CB3-B72E-4E1E-A1A7-3BFAF61FCFDAQ50483313-33054CFF-562C-4476-9138-D222E19853A3Q51365910-05C97D2E-BE8E-4DDF-8EC4-82B59F74BA36Q54525376-E7858B3F-361D-44E9-A991-9A65D1780877
P2860
Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/09/30)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/30)
@nl
наукова стаття, опублікована у вересні 2010
@uk
مقالة علمية (نشرت في 30-9-2010)
@ar
name
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@ast
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@en
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@nl
type
label
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@ast
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@en
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@nl
prefLabel
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@ast
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@en
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@nl
P2093
P2860
P356
P1433
P1476
Janus kinase 2 is required for ...... olactin-induced mammary cancer
@en
P2093
A A Triplett
K Sakamoto
L A Schuler
P2860
P2888
P304
P356
10.1038/ONC.2010.274
P407
P50
P577
2010-07-19T00:00:00Z
P5875
P6179
1042923379