Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
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Secretory IgA: Designed for Anti-Microbial DefenseAccumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice.I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activationEmerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune HomeostasisB-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM ProductionGut microbiota elicits a protective immune response against malaria transmissionImmune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.Sequence-specific binding of normal serum immunoglobulin M to exposed protein C-termini.The acquisition of narrow binding specificity by polyspecific natural IgM antibodies in a semi-physiological environment.Identity of the elusive IgM Fc receptor (FcmuR) in humans.AID-induced remodeling of immunoglobulin genes and B cell fate.Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.The B-cell system of human mucosae and exocrine glands.B cells and humoral immunity in atherosclerosisSecreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.IgM expression in paraffin sections distinguishes follicular lymphoma from reactive follicular hyperplasiaIgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3Requirement for complement in antibody responses is not explained by the classic pathway activator IgM.The long elusive IgM Fc receptor, FcμR.The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.Antibody diversification and selection in the mature B-cell compartment.Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytesIgE-mediated enhancement of antibody responses: the beneficial function of IgE?Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.The role of B cells and humoral immunity in Mycobacterium tuberculosis infectionComplement-activating IgM enhances the humoral but not the T cell immune response in mice.Natural autoantibodies as tools to predict the outcome of immune response?Autopolyreactivity Confers a Holistic Role in the Immune System.The versatile roles of antibodies in Borrelia infections.Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties.Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR).Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responsesB-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infectionGerminal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells.A role for complement in feedback enhancement of antibody responses by IgG3.Specific IgM and Regulation of Antibody Responses.A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease.MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses.Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses.
P2860
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P2860
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
description
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1998
@ast
im August 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/08/18)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/08/18)
@nl
наукова стаття, опублікована в серпні 1998
@uk
name
Targeted gene disruption revea ...... of the primary immune response
@ast
Targeted gene disruption revea ...... of the primary immune response
@en
Targeted gene disruption revea ...... of the primary immune response
@nl
type
label
Targeted gene disruption revea ...... of the primary immune response
@ast
Targeted gene disruption revea ...... of the primary immune response
@en
Targeted gene disruption revea ...... of the primary immune response
@nl
prefLabel
Targeted gene disruption revea ...... of the primary immune response
@ast
Targeted gene disruption revea ...... of the primary immune response
@en
Targeted gene disruption revea ...... of the primary immune response
@nl
P2093
P2860
P3181
P356
P1476
Targeted gene disruption revea ...... of the primary immune response
@en
P2093
M S Neuberger
S L Davies
T L O'Keefe
P2860
P304
10089-10093
P3181
P356
10.1073/PNAS.95.17.10089
P407
P577
1998-08-01T00:00:00Z