Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism
about
Receptor complexes for each of the Class 3 SemaphorinsBrain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3ANRP1 function and targeting in neurovascular development and eye diseaseCentral hypogonadotropic hypogonadism: genetic complexity of a complex diseaseTranscriptional regulation of cranial sensory placode developmentNRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous systemThe Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system.VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vesselsA genome-wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines.NELF knockout is associated with impaired pubertal development and subfertility.Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome.Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertilitySEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndromeGnRH, anosmia and hypogonadotropic hypogonadism--where are we?Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome.Impaired sense of smell and altered olfactory system in RAG-1(-∕-) immunodeficient mice.Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspringSOX2 regulates the hypothalamic-pituitary axis at multiple levelsSemaphorin signaling in the development and function of the gonadotropin hormone-releasing hormone system.CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability.Invertebrate models of kallmann syndrome: molecular pathogenesis and new disease genes.Congenital diseases and semaphorin signaling: overview to date of the evidence linking them.The potential of class 3 semaphorins as both targets and therapeutics in cancer.Semaphorin3A-neuropilin1 signalling is involved in the generation of cortical interneurons.GnRH and GnRH receptors in the pathophysiology of the human female reproductive system.Semaphorins and their Signaling Mechanisms.The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons.Differential gene expression in migratory streams of cortical interneurons.Slit2 and Robo3 modulate the migration of GnRH-secreting neuronsThe terminal nerve plays a prominent role in GnRH-1 neuronal migration independent from proper olfactory and vomeronasal connections to the olfactory bulbs.Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice.A recognizable type of syndromic short stature with arthrogryposis caused by bi-allelic SEMA3A loss-of-function variants.Biallelic SEMA3A defects cause a novel type of syndromic short stature.Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism
P2860
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P2860
Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism
description
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Januar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/01/15)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/01/15)
@nl
наукова стаття, опублікована в січні 2011
@uk
مقالة علمية (نشرت في 15-1-2011)
@ar
name
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@ast
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@en
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@nl
type
label
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@ast
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@en
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@nl
prefLabel
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@ast
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@en
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Defective gonadotropin-releasi ...... hypogonadotropic hypogonadism
@en
P2093
John G Parnavelas
Kathryn Davidson
Sonja Rakic
P2860
P304
P3181
P356
10.1093/HMG/DDQ468
P577
2010-11-08T00:00:00Z