Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.
about
Beyond generalized hair cells: molecular cues for hair cell typesThe genetics of hair cell development and regenerationSegregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Conditional gene expression in the mouse inner ear using Cre-loxP.Sensory hair cell development and regeneration: similarities and differencesWhere hearing starts: the development of the mammalian cochleaScanning thin-sheet laser imaging microscopy elucidates details on mouse ear development.Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti developmentThe quest for restoring hearing: Understanding ear development more completely.Pax2 contributes to inner ear patterning and optic nerve trajectoryTargeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner earN-Myc and L-Myc are essential for hair cell formation but not maintenanceInner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectodermEvolution and development of the tetrapod auditory system: an organ of Corti-centric perspective.Three-dimensional reconstructions from optical sections of thick mouse inner ears using confocal microscopyThe molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of CortiDissecting the molecular basis of organ of Corti development: Where are we now?Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?The Role of Atonal Factors in Mechanosensory Cell Specification and FunctionA review of gene delivery and stem cell based therapies for regenerating inner ear hair cellsThe myc road to hearing restoration.Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.Regeneration of Hair Cells: Making Sense of All the Noise.Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.Mutational ataxia resulting from abnormal vestibular acquisition and processing is partially compensated forA novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.Continued expression of GATA3 is necessary for cochlear neurosensory developmentA new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular contextInner ear hair cells deteriorate in mice engineered to have no or diminished innervationAge-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expressionTFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1.The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti.Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
P2860
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P2860
Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Conditional deletion of Atoh1 ...... ost most of the organ of Corti
@nl
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@ast
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@en
type
label
Conditional deletion of Atoh1 ...... ost most of the organ of Corti
@nl
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@ast
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@en
prefLabel
Conditional deletion of Atoh1 ...... ost most of the organ of Corti
@nl
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@ast
Conditional deletion of Atoh1 ...... st most of the organ of Corti.
@en
P2093
P2860
P1433
P1476
Conditional deletion of Atoh1 ...... ost most of the organ of Corti
@en
P2093
Benjamin Kopecky
Heather Schmitz
Israt Jahan
Jennifer Kersigo
Peter Santi
Shane Johnson
P2860
P356
10.1016/J.HEARES.2010.12.002
P577
2010-12-10T00:00:00Z