Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
about
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsMutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functionsDNA mismatch repair: molecular mechanism, cancer, and ageingMSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instabilityMutS inhibits RecA-mediated strand transfer with methylated DNA substrates.PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsMolecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesisManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerPaving the Road to Tumor Development and Spreading: Myeloid-Derived Suppressor Cells are Ruling the FateA MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDNA replication fidelity and cancerNovel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions.Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicityInteraction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6.Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells.Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli.Cellular responses to Cisplatin-induced DNA damage.Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic ResponseMsh6 protects mature B cells from lymphoma by preserving genomic stability.O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20QMajor differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylatorMolecular devices for high fidelity of DNA replication and gene expression.The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complexMismatch-mediated error prone repair at the immunoglobulin genes.p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damageChlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient MiceBiochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapyMismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links.
P2860
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P2860
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/08/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/01)
@nl
наукова стаття, опублікована в серпні 2004
@uk
مقالة علمية (نشرت في أغسطس 2004)
@ar
name
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@ast
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@en
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@nl
type
label
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@ast
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@en
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@nl
prefLabel
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@ast
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@en
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@nl
P2093
P3181
P1433
P1476
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
@en
P2093
Guohze Yang
Martin Lipkin
Raju Kucherlapati
Richard D. Kolodner
Scarlet S. Shell
Stefan J. Scherer
Winfried Edelmann
P304
P3181
P356
10.1016/J.CCR.2004.06.024
P577
2004-08-01T00:00:00Z