Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
about
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signallingMED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signalingMediator kinase module and human tumorigenesisThe Mediator complex: a central integrator of transcriptionThe transcriptional mediator component Med12 is required for hindbrain boundary formationDisordered proteinaceous machinesCombinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.Porcine tissue-specific regulatory networks derived from meta-analysis of the transcriptome.Inhibition of canonical WNT signaling attenuates human leiomyoma cell growthHeart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila.Mediator and human diseaseMediator subunit 12 is required for neutrophil development in zebrafishWhole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.MED12 alterations in both human benign and malignant uterine soft tissue tumors.Mediator complex dependent regulation of cardiac development and disease.Mutations in prickle orthologs cause seizures in flies, mice, and humans.Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing marginTissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma.Probing transcription-specific outputs of β-catenin in vivo.Genomic copy number variation in Mus musculusEpidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.Med12 gain-of-function mutation causes leiomyomas and genomic instability.Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids.Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.Lessons on the pathogenesis of aneurysm from heritable conditionsVitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid CellsUterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction.Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growthMED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.Somatic Genetic Variation in Solid Pseudopapillary Tumor of the Pancreas by Whole Exome Sequencing.MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathwaysA consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.Planar cell polarity signaling in collective cell movements during morphogenesis and disease.MED12 regulates a transcriptional network of calcium-handling genes in the heart.Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/β-catenin signalling pathway.Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway.Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.
P2860
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P2860
Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
description
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im August 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/08/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/08/01)
@nl
наукова стаття, опублікована в серпні 2010
@uk
مقالة علمية (نشرت في أغسطس 2010)
@ar
name
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@ast
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@en
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@nl
type
label
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@ast
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@en
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@nl
prefLabel
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@ast
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@en
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@nl
P2093
P3181
P356
P1433
P1476
Med12 is essential for early m ...... ical Wnt and Wnt/PCP signaling
@en
P2093
Heinrich Schrewe
Manuela Scholze
Pedro P. Rocha
Wilfrid Bleiss
P304
P3181
P356
10.1242/DEV.053660
P407
P577
2010-08-01T00:00:00Z