Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails
about
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genesA genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair featuresDNase 2 is the main DNA-degrading enzyme of the stratum corneumThe post-apoptotic fate of RNAs identified through high-throughput sequencing of human hairIn situ labeling of DNA reveals interindividual variation in nuclear DNA breakdown in hair and may be useful to predict success of forensic genotyping of hairRecurrent functional divergence of early tetrapod keratins in amphibian toe pads and mammalian hair.Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation.AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation.Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.Differential Inflammatory-Response Kinetics of Human Keratinocytes upon Cytosolic RNA- and DNA-Fragment Induction.Efficient identification of somatic mutations in acute myeloid leukaemia using whole exome sequencing of fingernail derived DNA as germline control
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P2860
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails
description
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Juni 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/06/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/06/01)
@nl
наукова стаття, опублікована в червні 2011
@uk
مقالة علمية (نشرت في يونيو 2011)
@ar
name
Essential role of the keratino ...... uclear DNA from hair and nails
@ast
Essential role of the keratino ...... uclear DNA from hair and nails
@en
Essential role of the keratino ...... uclear DNA from hair and nails
@nl
type
label
Essential role of the keratino ...... uclear DNA from hair and nails
@ast
Essential role of the keratino ...... uclear DNA from hair and nails
@en
Essential role of the keratino ...... uclear DNA from hair and nails
@nl
prefLabel
Essential role of the keratino ...... uclear DNA from hair and nails
@ast
Essential role of the keratino ...... uclear DNA from hair and nails
@en
Essential role of the keratino ...... uclear DNA from hair and nails
@nl
P2093
P2860
P50
P356
P1476
Essential role of the keratino ...... uclear DNA from hair and nails
@en
P2093
Desmond J. Tobin
Hans-Christian Theussl
Heidemarie Rossiter
Heinz Fischer
Jennifer Scherz
Karin Jaeger
Marcela Hermann
Maria Buchberger
Minoo Ghannadan
Sandra Szabo
P2860
P2888
P304
P356
10.1038/JID.2011.13
P407
P577
2011-06-01T00:00:00Z
P5875
P6179
1035704303