Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.
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Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutonsThe toxicity of amyloid β oligomersDrug Development in Alzheimer's Disease: The Contribution of PET and SPECTModulatory effects of α7 nAChRs on the immune system and its relevance for CNS disordersα7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimumAmyloid beta: multiple mechanisms of toxicity and only some protective effects?The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membraneDendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout miceNeuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans.The nicotinic acetylcholine receptor: smoking and Alzheimer's disease revisitedThe novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampusNicotine: specific role in angiogenesis, proliferation and apoptosis.Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.Brain imaging of nicotinic receptors in Alzheimer's disease.Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function.Insulin resistance in Alzheimer's disease.Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammationα7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model.α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices.Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease.The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders.A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation.Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain.A role for calcineurin in Alzheimer's disease.Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models.Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication.Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease.The Luminescent Oligothiophene p-FTAA Converts Toxic Aβ1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors.Rejuvenating procholinergic treatments for cognition enhancement in AD: current challenges and future prospects.Preventing expression of the nicotinic receptor subunit α7 in SH-SY5Y cells with interference RNA indicates that this receptor may protect against the neurotoxicity of Aβ.Amyloid beta: structure, biology and structure-based therapeutic development.
P2860
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P2860
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
@yue
name
Loss of alpha7 nicotinic recep ...... e model of Alzheimer's disease
@nl
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@ast
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@en
type
label
Loss of alpha7 nicotinic recep ...... e model of Alzheimer's disease
@nl
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@ast
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@en
prefLabel
Loss of alpha7 nicotinic recep ...... e model of Alzheimer's disease
@nl
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@ast
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@en
P2093
P2860
P921
P3181
P1476
Loss of alpha7 nicotinic recep ...... model of Alzheimer's disease.
@en
P2093
Caterina M Hernandez
J David Sweatt
Kelly T Dineley
Rakez Kayed
P2860
P304
P3181
P356
10.1523/JNEUROSCI.5038-09.2010
P407
P577
2010-02-01T00:00:00Z