Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters - Wikidata - awgldk - TriplyDB

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

http://www.wikidata.org/entity/Q28592966

about

XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.Platelet function is modified by common sequence variation in megakaryocyte super enhancers Translational Perspective on Epigenetics in Cardiovascular Disease.The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome.Immunogenomic approaches to understand the function of immune disease variants.Chromosome contacts in activated T cells identify autoimmune disease candidate genes.Accurate and reproducible functional maps in 127 human cell types via 2D genome segmentation.Three-dimensional genome architecture and emerging technologies: looping in disease.Predicting stimulation-dependent enhancer-promoter interactions from ChIP-Seq time course data.Multiscale 3D Genome Rewiring during Mouse Neural Development.Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.Identification of copy number variations and translocations in cancer cells from Hi-C data.Nbeal2 interacts with Dock7, Sec16a, and Vac14.Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.The Three-Dimensional Organization of Mammalian Genomes.Chromatin-state discovery and genome annotation with ChromHMM.Functional mapping and annotation of genetic associations with FUMA.Transcriptome integration analysis in hepatocellular carcinoma reveals discordant intronic miRNA-host gene pairs in expression.Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.The three-dimensional genome: regulating gene expression during pluripotency and development.The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.Context-specific effects of genetic variants associated with autoimmune disease.Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines.Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity.New insights into the epigenetics of inflammatory rheumatic diseases.The interplay of epigenetic marks during stem cell differentiation and development.Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements.Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes.Chromatin dependencies in cancer and inflammation.Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Lessons from ten years of genome-wide association studies of asthma.Identifying noncoding risk variants using disease-relevant gene regulatory networks.Emerging Roles for Epigenetic Programming in the Control of Inflammatory Signaling Integration in Heath and Disease.Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation.Unmet Needs in Systemic Sclerosis Understanding and Treatment: the Knowledge Gaps from a Scientist's, Clinician's, and Patient's Perspective.Dissecting super-enhancer hierarchy based on chromatin interactions.Genetic variants in mRNA untranslated regions.Chromatin reprogramming in breast cancer.Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.Using regulatory genomics data to interpret the function of disease variants and prioritise genes from expression studies.

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Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

http://www.wikidata.org/entity/Q28592966

description

2016 nî lūn-bûn

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2016 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2016 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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Lineage-Specific Genome Archit ...... iants to Target Gene Promoters

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Lineage-Specific Genome Archit ...... iants to Target Gene Promoters

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Lineage-Specific Genome Archit ...... iants to Target Gene Promoters

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Lineage-Specific Genome Archit ...... iants to Target Gene Promoters

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An integrated encyclopedia of DNA elements in the human genome

Genetic studies of body mass index yield new insights for obesity biology

Multiple common variants for celiac disease influencing immune gene expression

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Biological, clinical and population relevance of 95 loci for blood lipids

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

A second generation human haplotype map of over 3.1 million SNPs

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Steven P Wilder

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Biola M. Javierre

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