mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression
about
Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock systemDNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivationSHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBPRescue of cardiac defects in id knockout embryos by injection of embryonic stem cellsBasic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1.Sharp-1 modulates the cellular response to DNA damage.A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.SHARP1 suppresses angiogenesis of endometrial cancer by decreasing hypoxia-inducible factor-1α levelDEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytesThe expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation.Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP.p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancerDEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor.Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatoninRegulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells.G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation.The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice.The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancersbHLH-Orange Transcription Factors in Development and Cancer.Sumoylation of the basic helix-loop-helix transcription factor sharp-1 regulates recruitment of the histone methyltransferase G9a and function in myogenesis.The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs.Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.BHLHB3: a candidate tumor suppressor in lung cancer.The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation.Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13.Adaptive myogenesis under hypoxia.Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors.Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity.The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.DEC2 modulates orexin expression and regulates sleep.
P2860
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P2860
mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Mai 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/05/30)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/05/30)
@nl
наукова стаття, опублікована в травні 2003
@uk
name
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@ast
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@en
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@nl
type
label
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@ast
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@en
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@nl
prefLabel
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@ast
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@en
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@nl
P2093
P2860
P356
P1476
mSharp-1/DEC2, a basic helix-l ...... activity and Stra13 expression
@en
P2093
P2860
P304
20098–20109
P356
10.1074/JBC.M210427200
P407
P577
2003-05-30T00:00:00Z