Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
about
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signalingMolecular mechanisms of inner ear developmentSegregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?Where hearing starts: the development of the mammalian cochleaA noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler miceCooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationPax2 contributes to inner ear patterning and optic nerve trajectoryInner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectodermShaping sound in space: the regulation of inner ear patterningUnderstanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Regeneration of Hair Cells: Making Sense of All the Noise.Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst.Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear.Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development.Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cellsReconstruction of the mouse otocyst and early neuroblast lineage at single-cell resolution.Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis.Point mutations in GLI3 lead to misregulation of its subcellular localization.Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway.Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neuronsGli activity is critical at multiple stages of embryonic mammary and nipple development.N-myc controls proliferation, morphogenesis, and patterning of the inner earConserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner.Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear.BMP regulates regional gene expression in the dorsal otocyst through canonical and non-canonical intracellular pathwaysMyosin II regulates extension, growth and patterning in the mammalian cochlear duct.Specification of cell fate in the mammalian cochleaCoordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells.Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle.Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle.Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling.Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.Embryological manipulations in the developing Xenopus inner ear reveal an intrinsic role for Wnt signaling in dorsal-ventral patterning.Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear.
P2860
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P2860
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
description
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/05/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/05/01)
@nl
наукова стаття, опублікована в травні 2007
@uk
مقالة علمية (نشرت في مايو 2007)
@ar
name
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@ast
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@en
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@nl
type
label
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@ast
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@en
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@nl
prefLabel
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@ast
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@en
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@nl
P2093
P921
P356
P1433
P1476
Opposing gradients of Gli repr ...... oventral axis of the inner ear
@en
P2093
Diane K Dolson
Doris K Wu
Douglas J Epstein
Patrick Hill
Ulrich Rüther
P304
P356
10.1242/DEV.000760
P407
P50
P577
2007-03-29T00:00:00Z