Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells

Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells

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http://www.wikidata.org/entity/Q28593434
The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functionsLethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene.Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathwayGeneration and degradation of free asparagine-linked glycans.Non-lysosomal Degradation of Singly Phosphorylated Oligosaccharides Initiated by the Action of a Cytosolic Endo-β-N-acetylglucosaminidaseProspective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylation.Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1.Generation of a Mutant Mucor hiemalis Endoglycosidase That Acts on Core-fucosylated N-Glycans.Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.Mitochondrial function requires NGLY1.Occurrence of free sialyl oligosaccharides related to N-glycans (sialyl free N-glycans) in animal sera.Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches.Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency.
P2860

Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells

Item
http://www.wikidata.org/entity/Q28593434
description
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2015
@ast
im Februar 2015 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2015/02/03)
@sk
vědecký článek publikovaný v roce 2015
@cs
wetenschappelijk artikel (gepubliceerd op 2015/02/03)
@nl
наукова стаття, опублікована в лютому 2015
@uk
name
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@ast
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@en
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@nl
type
label
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@ast
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@en
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@nl
prefLabel
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@ast
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@en
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Endo-β-N-acetylglucosaminidase ...... ation in Ngly1-defective cells
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932