Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity
about
Amyloid cannot resist identificationInhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusProteotoxic stress increases nuclear localization of ataxin-3Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy.Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophyPathways to motor incoordination: the inherited ataxias.Molecular pathogenesis of spinocerebellar ataxia type 6.Atrophin proteins: an overview of a new class of nuclear receptor corepressorsSevere neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice.Non-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells.Nuclear accumulation of polyglutamine disease proteins and neuropathology.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Huntington's disease, calcium, and mitochondria.Polyglutamine (PolyQ) diseases: genetics to treatments.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy.A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease.Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.DFNA5: hearing impairment exon instead of hearing impairment gene?Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat.Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.
P2860
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P2860
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity
description
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im April 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/04/11)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/04/11)
@nl
наукова стаття, опублікована у квітні 2003
@uk
name
Nuclear localization of a non- ...... t, increases cellular toxicity
@ast
Nuclear localization of a non- ...... t, increases cellular toxicity
@en
Nuclear localization of a non- ...... t, increases cellular toxicity
@nl
type
label
Nuclear localization of a non- ...... t, increases cellular toxicity
@ast
Nuclear localization of a non- ...... t, increases cellular toxicity
@en
Nuclear localization of a non- ...... t, increases cellular toxicity
@nl
prefLabel
Nuclear localization of a non- ...... t, increases cellular toxicity
@ast
Nuclear localization of a non- ...... t, increases cellular toxicity
@en
Nuclear localization of a non- ...... t, increases cellular toxicity
@nl
P2093
P2860
P50
P356
P1476
Nuclear localization of a non- ...... t, increases cellular toxicity
@en
P2093
Akira Sawa
Cheryl L. Wellington
Frederick C. Nucifora
Jon D. Wood
Lisa M. Ellerby
Valina L. Dawson
William J. Herring
P2860
P304
13047–13055
P356
10.1074/JBC.M211224200
P407
P577
2003-04-11T00:00:00Z