Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
about
The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expressionNovel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor)BPAG1n4 is essential for retrograde axonal transport in sensory neuronsHuman plectin: organization of the gene, sequence analysis, and chromosome localization (8q24)Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakinBPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activitiesMultiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesisThe N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosomeDefective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophyDelayed wound healing in CXCR2 knockout miceBinding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament bindingBreaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assemblyLaminin 5 binds the NC-1 domain of type VII collagenNesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectinMicrotubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletonsHemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakinThe localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunitAn epidermal plakin that integrates actin and microtubule networks at cellular junctionsMicrotubule plus-end tracking proteins in neuronal developmentCytoskeleton in motion: the dynamics of keratin intermediate filaments in epitheliaPhosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal TransitionGAR22β regulates cell migration, sperm motility, and axoneme structure.Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-OgnaNetworking galore: intermediate filaments and cell migrationTargeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitectureDemonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formationDesmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkageMapping genetic variants associated with beta-adrenergic responses in inbred miceProgressive kidney degeneration in mice lacking tensinThe intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neuronsEpiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissuesForced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytesElimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice.Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survivalkakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophinRetrolinkin, a membrane protein, plays an important role in retrograde axonal transportReversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodiesHerpesvirus tegument protein pUL37 interacts with dystonin/BPAG1 to promote capsid transport on microtubules during egress.Keratins mediate localization of hemidesmosomes and repress cell motility
P2860
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P2860
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
description
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1995
@ast
im April 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/04/21)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/04/21)
@nl
наукова стаття, опублікована у квітні 1995
@uk
مقالة علمية (نشرت في 21-4-1995)
@ar
name
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@ast
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@en
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@nl
type
label
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@ast
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@en
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@nl
prefLabel
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@ast
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@en
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@nl
P2093
P1433
P1476
Gene targeting of BPAG1: abnor ...... ia and neurologic degeneration
@en
P2093
J. Dowling
L. Degenstein
R. Wollmann
P304
P356
10.1016/0092-8674(95)90333-X
P407
P577
1995-04-21T00:00:00Z