The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
about
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression.Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation.A genomic survey of HECT ubiquitin ligases in eukaryotes reveals independent expansions of the HECT system in several lineages.
P2860
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
description
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2011
@ast
im Januar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/01/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/01/01)
@nl
наукова стаття, опублікована в січні 2011
@uk
name
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@ast
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@en
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@nl
type
label
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@ast
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@en
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@nl
prefLabel
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@ast
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@en
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@nl
P2093
P2860
P1433
P1476
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
@en
P2093
Akiko Murayama
Hiroyuki Kishimoto
Hisashi Oishi
Junn Yanagisawa
Mai Tsuchiya
Masashi Kajiro
Miyuki Katano
Naoya Iwasaki
Natsuka Goto
Ryohei Furumai
P2860
P304
P356
10.1371/JOURNAL.PONE.0025871
P407
P577
2011-01-01T00:00:00Z