Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
about
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulationPIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexesMutations in PRKCSH cause isolated autosomal dominant polycystic liver disease.The functions of TRPP2 in the vascular systemA polycystin-centric view of cyst formation and disease: the polycystins revisitedPolycystin-1 cleavage and the regulation of transcriptional pathwaysStructural and molecular basis of the assembly of the TRPP2/PKD1 complexPkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cellsNative polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epitheliaIdentification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel FunctionN-glycosylation determines the abundance of the transient receptor potential channel TRPP2Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Polycystic liver diseases.Polycystin-1 activates and stabilizes the polycystin-2 channel.Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility.Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.Intracellular calcium release modulates polycystin-2 trafficking.The versatile nature of the calcium-permeable cation channel TRPP2Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.A novel PKD2L1 C-terminal domain critical for trimerization and channel function.Molecular pathways and therapies in autosomal-dominant polycystic kidney diseaseHarvest and primary culture of the murine aldosterone-sensitive distal nephronHair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.Regulation of Polycystin-1 Function by Calmodulin Binding.Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.Cystic kidney diseases: many ways to form a cyst.Regulation of transport in the connecting tubule and cortical collecting ductG-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.Cell biology of polycystin-2.Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.Polycystin-2 immunolocalization and function in zebrafishPurinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts.
P2860
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P2860
Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
description
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im Juni 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/06/07)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/06/07)
@nl
наукова стаття, опублікована в червні 2002
@uk
name
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@ast
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@en
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@nl
type
label
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@ast
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@en
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@nl
prefLabel
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@ast
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@en
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@nl
P2093
P2860
P921
P3181
P356
P1476
Identification, characterizati ...... ycystin-1-polycystin-2 complex
@en
P2093
Albert C. M. Ong
Andrew J. Streets
Christopher J. Ward
Linda J. Newby
Peter C. Harris
P2860
P304
20763–20773
P3181
P356
10.1074/JBC.M107788200
P407
P577
2002-06-07T00:00:00Z