Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
about
A role for Tbx5 in proepicardial cell migration during cardiogenesisTBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repressionMutation in myosin heavy chain 6 causes atrial septal defectA WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndromeFunctional analysis of TBX5 missense mutations associated with Holt-Oram syndromeCooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formationEpigenetic mechanisms in cardiac development and diseaseInvestigating the transcriptional control of cardiovascular developmentReconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes)Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartDifferential expression and function of Tbx5 and Tbx20 in cardiac developmentMammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeatA novel de novo TBX5 mutation in a patient with Holt-Oram syndrome leading to a dramatically reduced biological functionThe pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse modelFunctional analysis of the novel TBX5 c.1333delC mutation resulting in an extended TBX5 protein.Gene expression in pediatric heart disease with emphasis on conotruncal defects.Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development.Expressivity of Holt-Oram syndrome is not predicted by TBX5 genotypeSynergistic activation of cardiac genes by myocardin and Tbx5.Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois.In vitro site selection of a consensus binding site for the Drosophila melanogaster Tbx20 homolog midlineTbx4 interacts with the short stature homeobox gene Shox2 in limb development.Optomotor-blind in the development of the Drosophila HS and VS lobula plate tangential cells.Cardiac chamber formation: development, genes, and evolution.TBX5 drives Scn5a expression to regulate cardiac conduction system functionIdentification of direct T-box target genes in the developing zebrafish mesoderm.The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development.Mechanisms of T-box gene function in the developing heart.Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function.Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation.TBX5: A Key Regulator of Heart Development.Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.Physical interaction between TBX5 and MEF2C is required for early heart development.Microarray analysis of Tbx5-induced genes expressed in the developing heart.p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population.
P2860
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P2860
Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
description
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im September 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/09/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/09/01)
@nl
наукова стаття, опублікована у вересні 2001
@uk
مقالة علمية (نشرت في سبتمبر 2001)
@ar
name
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@ast
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@en
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@nl
type
label
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@ast
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@en
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@nl
prefLabel
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@ast
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@en
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@nl
P2093
P3181
P356
P1476
Characterization of the TBX5 b ...... that cause Holt-Oram syndrome
@en
P2093
A. J. Bonser
E. A. Packham
J. D. Brook
S. J. Cross
T. E. Robinson
T. K. Ghosh
P304
P3181
P356
10.1093/HMG/10.18.1983
P577
2001-09-01T00:00:00Z