Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
about
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activationActivation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylationMED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signalingMED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activationA Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegansArginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growthThe Mediator complex: a central integrator of transcriptionMediator-dependent nuclear receptor functionStructural considerations of vitamin D signalingThe Mediator complex and transcription regulationA cardiac microRNA governs systemic energy homeostasis by regulation of MED13Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiationThe nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor ComplexMediator complex dependent regulation of cardiac development and disease.Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development.Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.A Mediator-responsive form of metazoan RNA polymerase II.PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors.Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis.Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 geneIdentification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator.Med1 plays a critical role in the development of tamoxifen resistance.Transcriptional regulation and the role of diverse coactivators in animal cells.Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*.Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression.Evolution of disorder in Mediator complex and its functional relevanceRoles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization.Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α.The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation.Gene-specific transcription activation via long-range allosteric shape-shifting.Mechanisms of Mediator complex action in transcriptional activation.Plant Mediator complex and its critical functions in transcription regulation.Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage.PIC Activation through Functional Interplay between Mediator and TFIIH.ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly.Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation
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P2860
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/09/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/09/01)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في سبتمبر 2004)
@ar
name
Structural and functional orga ...... targeted by nuclear receptors
@ast
Structural and functional orga ...... targeted by nuclear receptors
@en
Structural and functional orga ...... targeted by nuclear receptors
@nl
type
label
Structural and functional orga ...... targeted by nuclear receptors
@ast
Structural and functional orga ...... targeted by nuclear receptors
@en
Structural and functional orga ...... targeted by nuclear receptors
@nl
prefLabel
Structural and functional orga ...... targeted by nuclear receptors
@ast
Structural and functional orga ...... targeted by nuclear receptors
@en
Structural and functional orga ...... targeted by nuclear receptors
@nl
P2093
P2860
P1476
Structural and functional orga ...... targeted by nuclear receptors
@en
P2093
Chao-Xing Yuan
Mohamed Guermah
Robert G. Roeder
Sohail Malik
Soichiro Yamamura
Weizhen Wu
P2860
P304
P356
10.1128/MCB.24.18.8244-8254.2004
P407
P577
2004-09-01T00:00:00Z