The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
about
Network features of the mammalian circadian clockp75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networksRole of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 geneCircadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligaseA molecular mechanism for circadian clock negative feedbackCompeting E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasmA positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machineryDual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clockSetting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteinsDual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complexCasein kinase 1 delta regulates the pace of the mammalian circadian clockA genome-wide RNAi screen for modifiers of the circadian clock in human cellsReciprocal interactions between circadian clocks and agingReciprocal Control of the Circadian Clock and Cellular Redox State - a Critical AppraisalCircadian Control of Global TranscriptionThe Molecular Circadian Clock and Alcohol-Induced Liver InjuryMolecular architecture of the mammalian circadian clockModelling age-related metabolic disorders in the mouseDisturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant miceTime-of-day- and light-dependent expression of ubiquitin protein ligase E3 component N-recognin 4 (UBR4) in the suprachiasmatic nucleus circadian clockCardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by β-Adrenergic Signaling, and Synchronized in Cardiac Ventricle TissueSCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocketCrystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligaseReversible protein phosphorylation regulates circadian rhythmsEntrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymesSleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's diseaseThe cost of circadian desynchrony: Evidence, insights and open questionsRoles of protein ubiquitination and degradation kinetics in biological oscillationsThe CRTC1-SIK1 pathway regulates entrainment of the circadian clockEvidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillatorsThe Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven AxisDYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeepingCell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock modelsLigand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic mannerRhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanismPhosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period lengthTemporal orchestration of repressive chromatin modifiers by circadian clock Period complexesSynaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2.
P2860
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P2860
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
description
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2007
@ast
im Mai 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/05/11)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/05/11)
@nl
наукова стаття, опублікована в травні 2007
@uk
name
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@ast
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@en
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@nl
type
label
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@ast
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@en
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@nl
prefLabel
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@ast
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@en
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@nl
P2093
P50
P3181
P356
P1433
P1476
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
@en
P2093
Alun R. Barnard
Debra Brooker
Elizabeth S. Maywood
Johanna E. Chesham
Linda Shaw
Luca Busino
M. Rosario Romero
Mohamed M. Quwailid
Patrick M. Nolan
Rachel Kendall
P304
P3181
P356
10.1126/SCIENCE.1141138
P407
P577
2007-05-11T00:00:00Z