Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
about
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failureUnderstanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorGenetics and disease of ventricular muscle.Genetic Variations Leading to Familial Dilated CardiomyopathyGenetic determinants of myocardial dysfunction.Insights into human beta-cardiac myosin function from single molecule and single cell studies.Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac musclesN-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size.Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.Chromatin regulation by Brg1 underlies heart muscle development and diseaseCardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHsGénie: literature-based gene prioritization at multi genomic scaleTwo Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.Structural basis for myopathic defects engendered by alterations in the myosin rodGenetic mutations and mechanisms in dilated cardiomyopathyHeuristic methods for finding pathogenic variants in gene coding sequences.Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy.Animal models of arrhythmogenic cardiomyopathy.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.Fluorescence spectra of cardiac myosin and in vivo experiment: studies on daunorubicin-induced cardiotoxicity.The genetic landscape of cardiomyopathy and its role in heart failure.DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy.Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.It's never too early to look: subclinical disease in sarcomeric dilated cardiomyopathy.Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy.
P2860
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P2860
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
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2006 nî lūn-bûn
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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Cardiac myosin missense mutati ...... press molecular motor function
@nl
Cardiac myosin missense mutati ...... ress molecular motor function.
@ast
Cardiac myosin missense mutati ...... ress molecular motor function.
@en
type
label
Cardiac myosin missense mutati ...... press molecular motor function
@nl
Cardiac myosin missense mutati ...... ress molecular motor function.
@ast
Cardiac myosin missense mutati ...... ress molecular motor function.
@en
prefLabel
Cardiac myosin missense mutati ...... press molecular motor function
@nl
Cardiac myosin missense mutati ...... ress molecular motor function.
@ast
Cardiac myosin missense mutati ...... ress molecular motor function.
@en
P2093
P2860
P3181
P356
P1476
Cardiac myosin missense mutati ...... press molecular motor function
@en
P2093
Amy Armstrong
Andrea Frederico
Christine E Seidman
David A Conner
David Warshaw
Edward P Debold
J G Seidman
Joachim P Schmitt
Ulrike Mende
P2860
P304
14525-14530
P3181
P356
10.1073/PNAS.0606383103
P407
P577
2006-09-18T00:00:00Z