Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels
about
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cellsFamilial hemiplegic migraine and spreading depressionSpreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP modelsAbnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant miceDelayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraineRole of voltage-gated calcium channels in epilepsy.Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.Translational imaging studies of cortical spreading depression in experimental models for migraine aura.Migraine: new molecular mechanisms.Familial hemiplegic migraine.Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.P/Q Ca2+ channel blockade stops spreading depression and related pyramidal neuronal Ca2+ rise in hippocampal organ culture.Cortical spreading depression activates and upregulates MMP-9.Animal models of generalized dystonia.Cortical spreading depression-new insights and persistent questions.Migraine and epilepsy: genetically linked?Genetics of migraine: possible links to neurophysiological abnormalities.Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.Emerging drugs in migraine treatment.Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients.The molecular genetics of migraine.Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice.An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation.Voltage-gated calcium channels and idiopathic generalized epilepsies.Genetics of migraine: an update.Zn2+ influx is critical for some forms of spreading depression in brain slices.Cortical spreading depression as a target for anti-migraine agents.Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.Noninvasive delivery of gene targeting probes to live brains for transcription MRIRegenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression.Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury.Animal models of headache: from bedside to bench and back to bedside.Pearls and pitfalls in experimental models of spreading depression.The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseasesTemporal fate specification and neural progenitor competence during development.Comparison of Spreading Depolarizations in the Motor Cortex and Nucleus Accumbens: Similar Patterns of Oxygen Responses and the Role of Dopamine.Single-Gene Determinants of Epilepsy Comorbidity.
P2860
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P2860
Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels
description
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Jahr 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/01/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/01/01)
@nl
наукова стаття, опублікована в січні 2000
@uk
مقالة علمية (نشرت عام 2000)
@ar
name
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@ast
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@en
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@nl
type
label
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@ast
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@en
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@nl
prefLabel
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@ast
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@en
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@nl
P2093
P1433
P1476
Impaired neurotransmitter rele ...... t of P/Q type calcium channels
@en
P2093
J. L. Noebels
M. A. Moskowitz
M. Shimizu-Sasamata
P304
P356
10.1016/S0306-4522(99)00446-7
P407
P577
2000-01-01T00:00:00Z