Kindlin-3 is essential for integrin activation and platelet aggregation
about
Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationA point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humansLeukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuityMigfilin, a molecular switch in regulation of integrin activationSHARPIN is an endogenous inhibitor of β1-integrin activationThe integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsPlatelet signaling: a complex interplay between inhibitory and activatory networksIntegrin-based therapeutics: biological basis, clinical use and new drugsThe unfolded von Willebrand factor response in bloodstream: the self-association perspectiveNormal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tailsStructure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainStructures and Interaction Analyses of Integrin M 2 Cytoplasmic TailsCrystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationBiology and structure of leukocyte β 2 integrins and their role in inflammationChemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrestKindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cellsKindlin-2 controls bidirectional signaling of integrinsKindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferationIntegrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesionsIntegrins in cell migrationTalin depletion reveals independence of initial cell spreading from integrin activation and traction.Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytesPhosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.Association between α4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migrationThe kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafishOsteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturationKindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.A directional switch of integrin signalling and a new anti-thrombotic strategy.Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction.
P2860
Q24294733-B70BB70C-678D-4159-945D-BA3750618805Q24313548-82713A9F-2540-4DC8-9FD3-D3FB9CEBC207Q24313629-2AE3FDB7-86F3-42A3-8DAC-A675B6BE6CE8Q24314265-FC75D703-97D9-43B2-A9D4-A55F5C61E09BQ24322932-F65B0066-42D3-4893-A175-40E21E261AE2Q24328844-80FE3849-CC24-45E5-B774-4DB5C7869466Q24338618-E9F6F563-6401-45CA-8EFC-E3B03FBD6D68Q24598442-764D5AD7-C3B7-4B14-AA2C-FB762F5A289DQ24657848-E389AA93-AE1C-4136-83E6-EBD7D056546BQ26765384-80E3E1BB-373C-41BB-90F7-A6592DE5E7B0Q26773026-1D92AA95-991A-4F07-AA4D-174C095E22CEQ26852187-7F5215E7-5BB1-460B-8789-6B3BF1B7ED09Q27302230-C22577D1-CF26-40DC-8C97-4F0F880F9A9CQ27308783-F749F4AD-AACD-4038-8917-39A2A8B166CDQ27653113-CFC079BA-3F59-4184-8879-6759A1F2A85CQ27653293-5C75579A-4E9F-4D7A-88DD-FBEA788468E1Q27675000-67887308-0443-4F63-ADE1-9A6D979A5CA3Q27675372-DF95E837-C936-46AF-9855-202082AA747CQ27679390-85057B49-D8F2-4E73-A4FD-039FA9A4434EQ28079100-FBB568D7-802D-461F-A1ED-058D750DABCEQ28270866-702E4102-03E5-440E-844B-6B1C234F126DQ28507135-ACFFCF62-C8FD-4093-8B7F-5EF1982CE975Q28507652-9E25F602-9121-4D78-87A1-84E946FC9155Q28910190-B0A79D27-CE4A-42D8-B856-1FD304673D8BQ30371366-ACB5B923-F367-4547-A733-BA0B6A4176BFQ30417364-3967F7A7-4160-454D-B38D-B0987E683A82Q30490335-ED5F9113-0E57-4712-BCC3-8C23A8365CC3Q30490515-64ACB244-A65D-4C07-82B7-D4DE54E7BF6AQ30492793-F4CB392E-598D-4AA5-8822-D97F490EE8D6Q30497918-23A7809F-B4CE-4B73-9E09-CF7E65E1B2F1Q30498119-4C052EF5-7BE4-4E03-9837-5BDBD72A3237Q30500398-44BB4049-5460-4B08-80AA-776B681DA2C2Q30502880-629B0E4C-5EE1-4A23-9DD1-986F6FE7409CQ30514206-5EA1CE8C-BDCF-4AAB-ABC4-7B2900D36A60Q30538811-50967080-B4FD-4CE3-A20E-070251BDEF07Q30552379-A13FDF72-1996-4740-BB1C-5B1641B2CA37Q30557151-9C498E3A-979A-42E3-A56C-8BDD0A84C922Q30854334-FB47B4F4-56A2-417E-8653-061A4D785BE1Q33381441-A12BAED7-0E82-4E58-B83A-DB89342B6879Q33389852-8A1274C7-33F9-4850-8D27-A85CC4F127FC
P2860
Kindlin-3 is essential for integrin activation and platelet aggregation
description
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im März 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/03/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/03/01)
@nl
наукова стаття, опублікована в березні 2008
@uk
مقالة علمية (نشرت في مارس 2008)
@ar
name
Kindlin-3 is essential for integrin activation and platelet aggregation
@ast
Kindlin-3 is essential for integrin activation and platelet aggregation
@en
Kindlin-3 is essential for integrin activation and platelet aggregation
@nl
type
label
Kindlin-3 is essential for integrin activation and platelet aggregation
@ast
Kindlin-3 is essential for integrin activation and platelet aggregation
@en
Kindlin-3 is essential for integrin activation and platelet aggregation
@nl
prefLabel
Kindlin-3 is essential for integrin activation and platelet aggregation
@ast
Kindlin-3 is essential for integrin activation and platelet aggregation
@en
Kindlin-3 is essential for integrin activation and platelet aggregation
@nl
P2093
P921
P3181
P356
P1433
P1476
Kindlin-3 is essential for integrin activation and platelet aggregation
@en
P2093
Bernhard Nieswandt
Markus Moser
Miroslava Pozgajova
P2888
P304
P3181
P356
10.1038/NM1722
P407
P577
2008-03-01T00:00:00Z