De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
about
Why reinvent the wheel? Building new proteins based on ready-made partsFolding and Stabilization of Native-Sequence-Reversed Proteins.Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone TemplateThe TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated MetabolismClusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability.The Folding of de Novo Designed Protein DS119 via Molecular Dynamics SimulationsBiosynthetic engineering of nonribosomal peptide synthetases.Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity.Principles for designing proteins with cavities formed by curved β sheets.Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints.Creation of active TIM barrel enzymes through genetic fusion of half-barrel domain constructs derived from two distantly related glycosyl hydrolases.Comprehensive computational design of ordered peptide macrocycles.Diversity in αβ and βα Loop Connections in TIM Barrel Proteins: Implications for Stability and Design of the Fold.Rules for connectivity of secondary structure elements in protein: Two-layer αβ sandwiches.Cyclic oligomer design with de novo αβ-proteins.Designed Heme-Cage β-Sheet Miniproteins.Designing cooperatively folded abiotic uni- and multimolecular helix bundles.Design of Self-Assembling Protein-Polymer Conjugates.Protein Design: Getting to the bottom of the TIM barrel.Computer-aided biochemical programming of synthetic microreactors as diagnostic devices.Design of a heme-binding peptide motif adopting a β-hairpin conformation.Blind prediction of noncanonical RNA structure at atomic accuracy.Highly active enzymes by automated combinatorial backbone assembly and sequence designFrom protein domains to molecular nanoparticles: what can giant molecules learn from proteins?Designed for life: biocompatible de novo designed proteins and components
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P2860
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@ast
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@en
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@nl
type
label
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@ast
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@en
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@nl
prefLabel
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@ast
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@en
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@nl
P2860
P50
P921
P3181
P356
P1476
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
@en
P2093
D Alejandro Fernandez Velasco
Kaspar Feldmeier
P2860
P2888
P3181
P356
10.1038/NCHEMBIO.1966
P407
P577
2016-01-01T00:00:00Z