Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicologyStructural Perturbations Induced by the α-Anomer of the Aflatoxin B 1 Formamidopyrimidine Adduct in Duplex and Single-Strand DNABypass of Aflatoxin B 1 Adducts by the Sulfolobus solfataricus DNA Polymerase IVMutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.Contributions of human enzymes in carcinogen metabolismA kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication.Allosteric phenomena in cytochrome P450-catalyzed monooxygenations.Fish models for environmental carcinogenesis: the rainbow trout.Inhibition of human cytochrome P450 3A4 by cholesterolStructure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.DNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 Adduct7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2.Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis.Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kineticsProtective Effect of Korean Red Ginseng against Aflatoxin B1-Induced Hepatotoxicity in RatBioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B₁.In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.Cooperative properties of cytochromes P450.The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review.Modulation of carcinogen-metabolizing cytochromes P450 by phytochemicals in humans.Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences.A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.New applications of bacterial systems to problems in toxicology.Aflatoxin B1: toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni.Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancerEffect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.Thermal stabilization of the DNA duplex by adducts of aflatoxin B1.Investigation of Non-Covalent Interactions of Aflatoxins (B1, B2, G1, G2, and M1) with Serum Albumin.Interaction Effects of AFB1 and MC-LR Co-exposure with Polymorphism of Metabolic Genes on Liver Damage: focusing on SLCO1B1 and GSTP1.7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites.CYP1A2 hydroxylates AFB1 to AFM1CYP1A2; 3A4 oxidise AFB1 to AFNBOThe effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey.Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates.Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes.Aflatoxin B1 exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption.Aflatoxin B1 can be complexed with oxidised tea polyphenols and the absorption of the complexed aflatoxin B1 is inhibited in rats.
P2860
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P2860
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
description
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1995
@ast
im März 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/03/01)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/03/01)
@nl
наукова стаття, опублікована в березні 1995
@uk
مقالة علمية (نشرت في مارس 1995)
@ar
name
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@ast
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@en
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@nl
type
label
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@ast
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@en
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@nl
prefLabel
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@ast
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@en
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@nl
P2093
P3181
P356
P1476
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
@en
P2093
F. P. Guengerich
H. Yamazaki
T. Shimada
Y. F. Ueng
P304
P3181
P356
10.1021/TX00044A006
P577
1995-03-01T00:00:00Z