Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins
about
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxinGlycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FStructure of dual receptor binding to botulinum neurotoxin BSpinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processingAn assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin.Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestineUnique ganglioside binding by botulinum neurotoxins C and D-SAIdentification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C.Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system.Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pHSynaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.Clinical uses of botulinum neurotoxins: current indications, limitations and future developmentsSubunit vaccine against the seven serotypes of botulismMechanism of botulinum neurotoxin B and G entry into hippocampal neuronsIntegration of ganglioside GT1b receptor into DPPE and DPPC phospholipid monolayers: an X-ray reflectivity and grazing-incidence diffraction study.Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons.Association of botulinum neurotoxins with synaptic vesicle protein complexes.Receptor and substrate interactions of clostridial neurotoxins.Receptor mimicry as novel therapeutic treatment for biothreat agents.Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach.Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers.Aβ1-25-Derived Sphingolipid-Domain Tracer Peptide SBD Interacts with Membrane Ganglioside Clusters via a Coil-Helix-Coil Motif.Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor.Characterization of neutralizing monoclonal antibodies directed against tetanus toxin fragment C.Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins.Protein Structure Facilitates High-Resolution Immunological Mapping.Characterization of the functional activity of botulinum neurotoxin subtype B6.Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.BoNT/A HC:LC binds SV2A; B; or C and GT1b on the target cell surfaceBoNT/B HC:LC binds SYT1 or 2 and GT1b on the target cell surfaceAntibodies against gangliosides in patients with dementia.
P2860
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P2860
Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins
description
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
scientific journal article
@en
vedecký článok (publikovaný 1998/08/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/08/01)
@nl
наукова стаття, опублікована в серпні 1998
@uk
مقالة علمية (نشرت في أغسطس 1998)
@ar
name
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@ast
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@en
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@nl
type
label
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@ast
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@en
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@nl
prefLabel
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@ast
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@en
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@nl
P2093
P356
P1476
Ganglioside GT1b as a compleme ...... stridium botulinum neurotoxins
@en
P2093
P356
10.1006/MPAT.1998.0214
P577
1998-08-01T00:00:00Z