A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch
about
Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domainThe main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosineInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchBase excision repair of DNA in mammalian cells.Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells.Role of MED1 (MBD4) Gene in DNA repair and human cancer.Formation and repair of tobacco carcinogen-derived bulky DNA adductsHighly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Repair of endogenous DNA damage.Differential repair of etheno-DNA adducts by bacterial and human AlkB proteinsHuman thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.Vinyl chloride-a classical industrial toxicant of new interest.Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesisAlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.Cadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation.1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts.Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6.Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct.Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2.Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis.TDG glycosylase mediated recognition and binding of an ethenocytosineCleavage of ethenocytosine by TDG glycosylase
P2860
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P2860
A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1998
@ast
im November 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/11/10)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/11/10)
@nl
наукова стаття, опублікована в листопаді 1998
@uk
name
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@ast
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@en
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@nl
type
label
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@ast
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@en
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@nl
prefLabel
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@ast
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@en
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@nl
P2093
P2860
P356
P1476
A 55-kDa protein isolated from ...... ocytosine and the G/T mismatch
@en
P2093
H. Fraenkel-Conrat
P2860
P304
13561–13566
P356
10.1073/PNAS.95.23.13561
P407
P577
1998-11-10T00:00:00Z