Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
about
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperoneSmad3 allostery links TGF-beta receptor kinase activation to transcriptional controlSmad inhibition by the Ste20 kinase MisshapenTAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewalTranscriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivatorIdentification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase IISTRAP and Smad7 synergize in the inhibition of transforming growth factor beta signalingSynergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 geneTransforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding elementSpecificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteinsSmads bind directly to the Jun family of AP-1 transcription factorsDifferential regulation of follicle stimulating hormone by activin A and TGFB1 in murine gonadotropes.Targeting TGF-β signaling in cancerCrystal structure of the MH2 domain of Drosophila MadDifferential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cellsTGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradationPhysical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptorsSpecific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signalingOncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesisSmad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organizationMesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathwaysTargeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-betaDirect binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules.TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-betaSingle-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane.A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein.Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer.Mechanism for mutational inactivation of the tumor suppressor Smad2.Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transitionTGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway.Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions.Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair.A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival.Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
P2860
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P2860
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
description
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Oktober 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/10/31)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/10/31)
@nl
наукова стаття, опублікована в жовтні 1997
@uk
name
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@ast
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@en
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@nl
type
label
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@ast
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@en
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@nl
prefLabel
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@ast
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@en
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@nl
P2093
P3181
P356
P1476
Phosphorylation of Ser465 and ...... g growth factor-beta signaling
@en
P2093
C. H. Heldin
C. Wernstedt
P. ten Dijke
S. Souchelnytskyi
U. Engström
P304
28107–28115
P3181
P356
10.1074/JBC.272.44.28107
P407
P577
1997-10-31T00:00:00Z