Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
about
Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationEnhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domainTyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptorsTyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual ScreeningFrequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasiasAdvances in Skeletal Dysplasia GeneticsMultiple consequences of a single amino acid pathogenic RTK mutation: the A391E mutation in FGFR3Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasiaFGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesisConstitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimerasIncreased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndromeActivating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domainProfound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type IICharacterization of membrane protein interactions in plasma membrane derived vesicles with quantitative imaging Förster resonance energy transferEffect of the G375C and G346E achondroplasia mutations on FGFR3 activation.Insulin receptor activation with transmembrane domain ligands.Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domainGly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesisPhysical basis behind achondroplasia, the most common form of human dwarfism.A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 geneDirect assessment of the effect of the Gly380Arg achondroplasia mutation on FGFR3 dimerization using quantitative imaging FRET.The Fibroblast Growth Factor signaling pathwayRole of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A).Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.Neutron diffraction studies of fluid bilayers with transmembrane proteins: structural consequences of the achondroplasia mutation.A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3.Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas.KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome.Transmembrane peptides as inhibitors of ErbB receptor signaling.Signaling networks that control the lineage commitment and differentiation of bone cells.Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase.Unliganded EphA3 dimerization promoted by the SAM domain.Chimeras of the native form or achondroplasia mutant (G375C) of human fibroblast growth factor receptor 3 induce ligand-dependent differentiation of PC12 cells.Signaling and transcriptional regulation in osteoblast commitment and differentiationJoint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis.
P2860
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P2860
Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
description
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im Februar 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/02/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/02/01)
@nl
наукова стаття, опублікована в лютому 1996
@uk
مقالة علمية (نشرت في فبراير 1996)
@ar
name
Constitutive activation of fib ...... tation found in achondroplasia
@ast
Constitutive activation of fib ...... tation found in achondroplasia
@en
Constitutive activation of fib ...... tation found in achondroplasia
@nl
type
label
Constitutive activation of fib ...... tation found in achondroplasia
@ast
Constitutive activation of fib ...... tation found in achondroplasia
@en
Constitutive activation of fib ...... tation found in achondroplasia
@nl
prefLabel
Constitutive activation of fib ...... tation found in achondroplasia
@ast
Constitutive activation of fib ...... tation found in achondroplasia
@en
Constitutive activation of fib ...... tation found in achondroplasia
@nl
P2860
P1433
P1476
Constitutive activation of fib ...... tation found in achondroplasia
@en
P2093
D J Donoghue
M K Webster
P2860
P304
P356
10.1002/J.1460-2075.1996.TB00384.X
P407
P577
1996-02-01T00:00:00Z