Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2
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Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discoveryPolymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancersStructural and Biochemical Characterization of an Active Arylamine N-Acetyltransferase Possessing a Non-canonical Cys-His-Glu Catalytic TriadHomology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a cysteine protease catalytic domain and an active-site loopN-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulationArylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitroIntrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau FragmentationConserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family MembersIdentification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogensProbing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190.What differs on the enzymatic acetylation mechanisms for arylamines and arylhydrazines substrates? A theoretical studyN-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.An acetyltransferase conferring tolerance to toxic aromatic amine chemicals: molecular and functional studies.Insights into how protein dynamics affects arylamine N-acetyltransferase catalysis.Arylamine N-acetyltransferases: a structural perspective.Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp.A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine].Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid.Suppression of a cold-sensitive mutation in ribosomal protein S5 reveals a role for RimJ in ribosome biogenesis.Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines.Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2.Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis.AcetylationThe acetyl group from acetyl-CoA is transferred to the NAT1The acetyl group from acetyl-CoA is transferred to the NAT2Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues.
P2860
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P2860
Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2
description
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1992
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im April 1992 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1992/04/15)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/04/15)
@nl
наукова стаття, опублікована у квітні 1992
@uk
name
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@ast
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@en
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@nl
type
label
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@ast
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@en
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@nl
prefLabel
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@ast
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@en
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@nl
P3181
P1476
Site-directed mutagenesis of r ...... nism of polymorphic human NAT2
@en
P2093
D. M. Grant
J. M. Dupret
P304
P3181
P407
P577
1992-04-15T00:00:00Z