The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM)
about
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteinsComparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertasesIsolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytesThe role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cellsRecent strategies targeting HIV glycans in vaccine designComparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vectorEndoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function.Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity: implications for the molecular mechanism of viral escape from a fusion inhibitorA Moloney murine leukemia virus-based retroviral vector pseudotyped by the insect retroviral gypsy envelope can infect Drosophila cells.Mutations within the putative membrane-spanning domain of the simian immunodeficiency virus transmembrane glycoprotein define the minimal requirements for fusion, incorporation, and infectivity.Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.Exon level transcriptomic profiling of HIV-1-infected CD4(+) T cells reveals virus-induced genes and host environment favorable for viral replication.Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives.A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.Proteolytic processing of the human immunodeficiency virus envelope glycoprotein precursor decreases conformational flexibilityImportance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusioncDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinasesAlterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses.TGFbeta1 regulates gene expression of its own converting enzyme furin.Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.Structural principles controlling HIV envelope glycosylation.Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication.Effect of alpha-1 antitrypsin Portland variant (alpha 1-PDX) on HIV-1 replication.Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo.A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions.Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha 2-macroglobulin containing a furin recognition sequence in the bait region.An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.Cleavage of the viral Env gp160 precursor polyproteinComparison of Uncleaved and Mature Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimers.Production of complex viral glycoproteins in plants as vaccine immunogens
P2860
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P2860
The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM)
description
1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1994
@ast
im April 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/04/22)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/04/22)
@nl
наукова стаття, опублікована у квітні 1994
@uk
name
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@ast
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@en
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@nl
type
label
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@ast
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@en
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@nl
prefLabel
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@ast
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@en
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@nl
P2093
P1476
The convertases furin and PC1 ...... (HIV-1 SU) and gp41 (HIV-I TM)
@en
P2093
A Kompelli
G Marshall
J Cogniaux
J M Ruysschaert
M Vandenbranden
S C Howard
P304
12240-12247
P407
P577
1994-04-01T00:00:00Z