Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method
about
Engineering cells to improve protein expression.Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production.Dissection of the beta-globin replication-initiation region reveals specific requirements for replicator elements during gene amplificationHow a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells.Cloning and Characterization of a Human Genomic Sequence that Alleviates Repeat-Induced Gene Silencing.Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells.Amplification of a transgene within a long array of replication origins favors higher gene expression in animal cells.Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.Toward stable gene expression in CHO cells.Impact of using different promoters and matrix attachment regions on recombinant protein expression level and stability in stably transfected CHO cells.Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells.
P2860
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P2860
Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method
description
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
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artículu científicu espublizáu en 2012
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im Januar 2012 veröffentlichter wissenschaftlicher Artikel
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scientific article (publication date: 2012)
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vedecký článok (publikovaný 2012)
@sk
vědecký článek publikovaný v roce 2012
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wetenschappelijk artikel (gepubliceerd in 2012)
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наукова стаття, опублікована у 2012
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name
Efficient recombinant producti ...... /MAR gene amplification method
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Efficient recombinant producti ...... /MAR gene amplification method
@en
Efficient recombinant producti ...... /MAR gene amplification method
@nl
type
label
Efficient recombinant producti ...... /MAR gene amplification method
@ast
Efficient recombinant producti ...... /MAR gene amplification method
@en
Efficient recombinant producti ...... /MAR gene amplification method
@nl
prefLabel
Efficient recombinant producti ...... /MAR gene amplification method
@ast
Efficient recombinant producti ...... /MAR gene amplification method
@en
Efficient recombinant producti ...... /MAR gene amplification method
@nl
P2093
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Efficient recombinant producti ...... /MAR gene amplification method
@en
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Chiemi Noguchi
Noriaki Shimizu
Tetsuro Hamafuji
Yoshio Araki
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P304
P3181
P356
10.1371/JOURNAL.PONE.0041787
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P577
2012-01-01T00:00:00Z