Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancerEnergy and biologistsBulliesText mining for biology - the way forward: opinions from leading scientistsLife science infrastructures are differentEpigenetic reprogramming of HOXC10 in endocrine-resistant breast cancerThanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II.Transcriptome profiling of estrogen-regulated genes in human primary osteoblasts reveals an osteoblast-specific regulation of the insulin-like growth factor binding protein 4 geneGovernment rhetoric and their R&D expenditure. A score-card for governments' investments into science and future technologies.Animal rights, human wrongs? Introduction to the Talking Point on the use of animals in scientific research.Is the system dumbing down research?Transcription in four dimensions: nuclear receptor-directed initiation of gene expressionA persistent problem. Traditional gender roles hold back female scientistsRestoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null miceDynamics of estrogen receptor-mediated transcriptional activation of responsive genes in vivo: apprehending transcription in four dimensions.Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes.Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A.Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling.Transient cyclical methylation of promoter DNA.Cyclical DNA methylation of a transcriptionally active promoter.The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.Genome-wide identification of high-affinity estrogen response elements in human and mouse.Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha.Natural trans-spliced mRNAs are generated from the human estrogen receptor-alpha (hER alpha) gene.Brexit and research: goodbye EU money and colleagues?E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements.Barriers to translation of research.Lip sync conferences.The steps from translatable to translational research.A European institute of technology?Too complex to comprehend?Jack-of-all-trades.Familiar faces.Science for society.Wanted: a strategy for European science.Different perspectives.Blind faith in pills and potions.The missing link.Market economy for scientists.
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P50
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Irish molecular biologist
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moleculair bioloog
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Bernard Francis Xavier Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Frank Gannon
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Bernard Francis Xavier Gannon
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no97016481
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1947-01-01T00:00:00Z
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