Massive turnover of functional sequence in human and other mammalian genomes
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8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineageWhat fraction of the human genome is functional?On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODEDefining functional DNA elements in the human genomeA high-resolution map of human evolutionary constraint using 29 mammalsLineage-specific genomics: Frequent birth and death in the human genome: The human genome contains many lineage-specific elements created by both sequence and functional turnoverConserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks PrincipleNoncoding origins of anthropoid traits and a new null model of transposon functionalizationExaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong?Insights into the evolution of Darwin's finches from comparative analysis of the Geospiza magnirostris genome sequence29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genomeRapid turnover of long noncoding RNAs and the evolution of gene expressionIdentification of functional elements and regulatory circuits by Drosophila modENCODEGenome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm developmentA statistical framework to predict functional non-coding regions in the human genome through integrated analysis of annotation data.BIDCHIPS: bias decomposition and removal from ChIP-seq data clarifies true binding signal and its functional correlates.The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity.DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.The calculation of information and organismal complexity.A method for calculating probabilities of fitness consequences for point mutations across the human genomeSuRFing the genomics wave: an R package for prioritising SNPs by functionalityReptiles and mammals have differentially retained long conserved noncoding sequences from the amniote ancestor.Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computation.DNA shape, genetic codes, and evolutionEvolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networksGenome-wide comparative analysis reveals human-mouse regulatory landscape and evolution.Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genomeComprehensive identification and analysis of human accelerated regulatory DNAThe QTN program and the alleles that matter for evolution: all that's gold does not glitterDetermining the Effect of Natural Selection on Linked Neutral Divergence across SpeciesA resolution of the mutation load paradox in humansPersonal and population genomics of human regulatory variation.Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data.Interpreting noncoding genetic variation in complex traits and human disease.The mystery of extreme non-coding conservation.Integration of new genes into cellular networks, and their structural maturation.Heterogeneous tempo and mode of conserved noncoding sequence evolution among four mammalian orders.Genome-wide analysis of promoters: clustering by alignment and analysis of regular patterns.Variation in the mutation rate across mammalian genomes.
P2860
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P2860
Massive turnover of functional sequence in human and other mammalian genomes
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Massive turnover of functional sequence in human and other mammalian genomes
@ast
Massive turnover of functional sequence in human and other mammalian genomes
@en
Massive turnover of functional sequence in human and other mammalian genomes
@nl
type
label
Massive turnover of functional sequence in human and other mammalian genomes
@ast
Massive turnover of functional sequence in human and other mammalian genomes
@en
Massive turnover of functional sequence in human and other mammalian genomes
@nl
prefLabel
Massive turnover of functional sequence in human and other mammalian genomes
@ast
Massive turnover of functional sequence in human and other mammalian genomes
@en
Massive turnover of functional sequence in human and other mammalian genomes
@nl
P2860
P3181
P356
P1433
P1476
Massive turnover of functional sequence in human and other mammalian genomes
@en
P2093
Stephen Meader
P2860
P304
P3181
P356
10.1101/GR.108795.110
P407
P577
2010-10-01T00:00:00Z