A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex
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Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinThe budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO.The p97 ATPase associates with EEA1 to regulate the size of early endosomesEmerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemThe ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory groupThe requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubilityRegulation of Plant Cellular and Organismal Development by SUMO.Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Corepressor-directed preacetylation of histone H3 in promoter chromatin primes rapid transcriptional switching of cell-type-specific genes in yeast.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?Functions of the proteasome on chromatin.Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutantCellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.Destroying the ring: Freeing DNA from Ku with ubiquitin.Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4.Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functionsRevoking the cellular license to replicate: yet another AAA assignment.Structure and function of the AAA+ ATPase p97/Cdc48p.How the ubiquitin proteasome system regulates the regulators of transcription.Ubiquitin and proteasomes in transcriptionRole of p97/VCP (Cdc48) in genome stability.The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNPInteraction of Gcn4 with target gene chromatin is modulated by proteasome functionDNA damage emergency: cellular garbage disposal to the rescue?Cdc48: a swiss army knife of cell biology.The 26S proteasome and initiation of gene transcription.Regulation of transcriptional activators by DNA-binding domain ubiquitination.Ubiquitin signals proteolysis-independent stripping of transcription factors.Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction.Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope.SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.Termination of DNA replication forks: "Breaking up is hard to do".Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor
P2860
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P2860
A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@ast
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@en
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@nl
type
label
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@ast
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@en
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@nl
prefLabel
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@ast
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@en
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@nl
P2860
P3181
P356
P1433
P1476
A ubiquitin-selective AAA-ATPa ...... repressor-promoter DNA complex
@en
P2093
Alexander J Wilcox
Jeffrey D Laney
P2860
P2888
P304
P3181
P356
10.1038/NCB1997
P407
P577
2009-12-01T00:00:00Z
P5875
P6179
1001563516