Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
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Inside out: the role of nucleocytoplasmic transport in ALS and FTLDC9orf72's Interaction with Rab GTPases-Modulation of Membrane Traffic and AutophagyMultiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyThe ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB SignalingC9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumModelling amyotrophic lateral sclerosis: progress and possibilitiesAtaxin-2: From RNA Control to Human Health and DiseasePoly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase.Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyRab GTPases: The Key Players in the Molecular Pathway of Parkinson's Disease.C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.R Loops and Links to Human Disease.Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.Decoding ALS: from genes to mechanism.Rabs, Membrane Dynamics, and Parkinson's Disease.Could Sirtuin Activities Modify ALS Onset and Progression?C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method.Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic SignificanceMultifaceted role of SMCR8 as autophagy regulator.Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia.RNA Misprocessing in C9orf72-Linked Neurodegeneration.C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.TCR signalling network organization at the immunological synapses of murine regulatory T cells.The Enigmatic Role of C9ORF72 in AutophagyAutophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.Proteostasis disturbance in amyotrophic lateral sclerosis.Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD.Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.Endocytosis regulates TDP-43 toxicity and turnover.
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Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
description
2016 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2016
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im Juni 2016 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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wetenschappelijk artikel (gepubliceerd op 2016/06/15)
@nl
наукова стаття, опублікована в червні 2016
@uk
مقالة علمية (نشرت في 15-6-2016)
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name
Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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type
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Loss of C9ORF72 impairs autoph ...... ron dysfunction and cell death
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Adeline Page
Angeline Gaucherot
Camille Julie Corbier
Chantal Sellier
Edor Kabashi
Frank Ruffenach
Isabelle Kolb-Cheynel
Maria-Letizia Campanari
Mustapha Oulad-Abdelghani
Sorana Ciura
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10.15252/EMBJ.201593350
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P577
2016-04-21T00:00:00Z