The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508
about
Mechanisms of CFTR Folding at the Endoplasmic ReticulumDeubiquitinases sharpen substrate discrimination during membrane protein degradation from the ERRegulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapiesRNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)DNAJs: more than substrate delivery to HSPAProtein folding and quality control in the ERMechanisms for quality control of misfolded transmembrane proteinsThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyModulation of the maladaptive stress response to manage diseases of protein foldingExpression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structureHow Polyomaviruses Exploit the ERAD Machinery to Cause InfectionA yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis.A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum MembraneDevelopment of CFTR StructureTranscriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord.Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHRA chaperone trap contributes to the onset of cystic fibrosis.VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration.Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiaeHuman heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels.FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stabilityHallmarks of therapeutic management of the cystic fibrosis functional landscape.CFTR: folding, misfolding and correcting the ΔF508 conformational defect.The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channelsChaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasomeA cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis.Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.Cellular responses to misfolded proteins and protein aggregates.Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis.Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.Fixing cystic fibrosis by correcting CFTR domain assembly.Synonymous codon usage affects the expression of wild type and F508del CFTR.
P2860
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P2860
The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508
description
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Februar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2011/02/01)
@nl
наукова стаття, опублікована в лютому 2011
@uk
مقالة علمية (نشرت في فبراير 2011)
@ar
name
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@ast
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@en
type
label
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@ast
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@en
prefLabel
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@ast
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@en
P2093
P2860
P921
P3181
P356
P1476
The endoplasmic reticulum-asso ...... ation of nascent CFTRDeltaF508
@en
P2093
Chun-Yang Fan
Diane E. Grove
Douglas M. Cyr
Hong Yu Ren
P2860
P304
P3181
P356
10.1091/MBC.E10-09-0760
P577
2011-02-01T00:00:00Z